Initial Serum Ammonia as a Predictor of Neurologic Complications in Patients with Acute Glufosinate Poisoning

Glufosinate poisoning can cause neurologic complications that may be difficult to treat due to delayed manifestation. Studies assessing possible predictors of complications are lacking. Although serum ammonia level is a potential predictor of severe neurotoxicity, it has only been assessed via case...

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Bibliographic Details
Published in:Yonsei medical journal 2016, 57(1), , pp.254-259
Main Authors: Lee, Dong Keon, Youk, Hyun, Kim, Hyun, Kim, Oh Hyun, Go, Jin, Kim, Tae Hoon, Cha, Kyoungchul, Lee, Kang Hyun, Hwang, Sung Oh, Cha, Yong Sung
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Aminobutyrates - blood
Aminobutyrates - poisoning
Ammonia - blood
Emergency Service, Hospital
Female
Glasgow Coma Scale
Humans
Male
Middle Aged
Nausea - etiology
Neurotoxicity Syndromes - blood
Neurotoxicity Syndromes - immunology
Neurotoxicity Syndromes - physiopathology
Original
Respiratory Insufficiency - etiology
Retrospective Studies
Seizures - etiology
Severity of Illness Index
Vomiting - etiology
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Summary:Glufosinate poisoning can cause neurologic complications that may be difficult to treat due to delayed manifestation. Studies assessing possible predictors of complications are lacking. Although serum ammonia level is a potential predictor of severe neurotoxicity, it has only been assessed via case reports. Therefore, we investigated factors that predict neurologic complications in acute glufosinate-poisoned patients. We conducted a retrospective review of 45 consecutive glufosinate-poisoning cases that were diagnosed in the emergency department (ED) of Wonju Severance Christian Hospital between May 2007 and July 2014. Patients with a Glasgow Coma Scale (GCS) score of
ISSN:0513-5796
1976-2437
DOI:10.3349/ymj.2016.57.1.254