Studies on therapeutic effects and pathological features of an antithrombin preparation in septic disseminated intravascular coagulation patients

• Published in: Yonsei medical journal 2013, 54(3), , pp.686-689
• Main Authors: Sakamoto, Yuichiro, Inoue, Satoshi, Iwamura, Takashi, Yamashita, Tomoko, Nakashima, Atsushi, Nishimura, Yoichi, Koami, Hiroyuki, Imahase, Hisashi, Goto, Akiko, Yamada, Kosuke Chris, Mashiko, Kunihiro, Yokota, Hiroyuki
• Format: Article
• Language: English
• Subjects: Aged; Disseminated Intravascular Coagulation - complications; Disseminated Intravascular Coagulation - diagnosis; Disseminated Intravascular Coagulation - drug therapy; Female; Fibrinolytic Agents - therapeutic use; Humans; Male; Middle Aged; Original; Sepsis - complications; Sepsis - diagnosis; Sepsis - drug therapy; Time Factors; Treatment Outcome; 의학일반
• ISSN: 0513-5796; 1976-2437
• DOI: 10.3349/ymj.2013.54.3.686

Few reports have been made on the therapeutic effects as well as pathological features of an antithrombin preparation in patients diagnosed with septic disseminated intravascular coagulation (DIC) by the diagnostic criteria for acute DIC. A total of 88 sepsis patients who had received inpatient hospital care during the period from January 2000 through December 2008 were divided into two groups, an antithrombin group and a non-antithrombin group, to study the outcomes. Furthermore, the relationship between sepsis-related factors and DIC in 44 patients was studied. The antithrombin group contained 34 patients, and the non-antithrombin group contained 54 patients. The outcomes were significantly better in the antithrombin group. The levels of protein C were low in DIC patients. Our results suggest that early administration of antithrombin might improve outcomes of septic DIC patients in the diagnostic criteria for Japanese Association for Acute Medicine acute DIC.