Spurious elevation of glucose concentration during administration of high dose of ascorbic acid in a patient with type 2 diabetes on hemodialysis

We describe herein a case of life-threatening hypoglycemia due to spurious elevation of glucose concentration during the administration of ascorbic acid in a type 2 diabetic patient. A 31-year-old female was admitted for proliferative diabetic retinopathy treatment and prescribed high dose ascorbic...

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Bibliographic Details
Published in:Yonsei medical journal 2013, 54(5), , pp.1289-1292
Main Authors: Kim, Soo Kyoung, Hahm, Jong Ryeal, Kim, Ho-Su, Kim, Sungsu, Jung, Tae Sik, Jung, Jung Hwa, Lee, Hye Ryun, Kim, Deok Ryong
Format: Article
Language:English
Subjects:
Adult
Ascorbic Acid - administration & dosage
Ascorbic Acid - adverse effects
Ascorbic Acid - therapeutic use
Blood Glucose
Blood Glucose Self-Monitoring - instrumentation
Blood Glucose Self-Monitoring - standards
Case Report
Contraindications
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - drug therapy
Female
Humans
Hypoglycemia - diagnosis
Renal Dialysis
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Summary:We describe herein a case of life-threatening hypoglycemia due to spurious elevation of glucose concentration during the administration of ascorbic acid in a type 2 diabetic patient. A 31-year-old female was admitted for proliferative diabetic retinopathy treatment and prescribed high dose ascorbic acid. During hospitalization, she suddenly lost her consciousness and her glucose concentration was 291 mg/dL, measured using self-monitoring blood glucose (SMBG) device, while venous blood glucose concentration was 12 mg/dL. After intravenous injection of 50% glucose solution, the patient became alert. We reasoned that glucose measurement by SMBG device was interfered by ascorbic acid. Physicians should be aware of this interference; high dose ascorbic acid may cause spurious elevation of glucose concentration when measuring with SMBG devices.
ISSN:0513-5796
1976-2437
DOI:10.3349/ymj.2013.54.5.1289