A more appropriate cardiac troponin T level that can predict outcomes in end-stage renal disease patients with acute coronary syndrome

• Published in: Yonsei medical journal 2011, 52(4), , pp.595-602
• Main Authors: Ryu, Dong-Ryeol, Park, Jung Tak, Chung, Jung Hwa, Song, Eun Mi, Roh, Sun Hee, Lee, Jeong-Min, An, Hye Rim, Yu, Mina, Pyun, Wook Bum, Shin, Gil Ja, Kim, Seung-Jung, Kang, Duk-Hee, Choi, Kyu Bok
• Format: Article
• Language: English
• Subjects: Acute Coronary Syndrome - blood; Acute Coronary Syndrome - complications; Acute Coronary Syndrome - diagnosis; Acute Coronary Syndrome - mortality; Aged; Biomarkers - blood; Female; Humans; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - diagnosis; Kidney Failure, Chronic - mortality; Male; Middle Aged; Original; Prognosis; Retrospective Studies; Sensitivity and Specificity; Troponin T - blood; 의학일반
• ISSN: 0513-5796; 1976-2437
• DOI: 10.3349/ymj.2011.52.4.595

Cardiac troponin T (cTnT), a useful marker for diagnosing acute myocardial infarction (AMI) in the general population, is significantly higher than the usual cut-off value in many end-stage renal disease (ESRD) patients without clinically apparent evidence of AMI. The aim of this study was to evaluate the clinical usefulness of cTnT in ESRD patients with acute coronary syndrome (ACS). Two hundred eighty-four ESRD patients with ACS were enrolled between March 2002 and February 2008. These patients were followed until death or June 2009. Medical records were reviewed retrospectively. The cut-off value of cTnT for AMI was evaluated using a receiver operating characteristic (ROC) curve. We calculated Kaplan-Meier survival curves, and potential outcome predictors were determined by Cox proportional hazard analysis. AMIs were diagnosed in 40 patients (14.1%). The area under the curve was 0.98 in the ROC curve (p