Clinicopathological characteristics in combined hepatocellular-cholangiocarcinoma: a single center study in Korea

Combined hepatocellular-cholangiocarcinoma (CHCC) is an uncommon form of cancer, and its clinicopathological features have rarely been reported in detail. This study was undertaken to evaluate the clinicopathological characteristics and prognostic factors of CHCC. The clinicopathological features of...

Full description

Saved in:
Bibliographic Details
Published in:Yonsei medical journal 2011, 52(5), , pp.753-760
Main Authors: Park, Hana, Choi, Ki Hong, Choi, Sae-Byeol, Choi, Jong Won, Kim, Do Young, Ahn, Sang Hoon, Kim, Kyung Sik, Choi, Jin Sub, Han, Kwang-Hyub, Chon, Chae Yoon, Park, Jun Yong
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - pathology
Cholangiocarcinoma - mortality
Cholangiocarcinoma - pathology
Diagnosis, Differential
Female
Humans
Kaplan-Meier Estimate
Liver Neoplasms - mortality
Liver Neoplasms - pathology
Male
Middle Aged
Neoplasm Recurrence, Local - pathology
Original
Prognosis
Republic of Korea - epidemiology
Retrospective Studies
의학일반
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Combined hepatocellular-cholangiocarcinoma (CHCC) is an uncommon form of cancer, and its clinicopathological features have rarely been reported in detail. This study was undertaken to evaluate the clinicopathological characteristics and prognostic factors of CHCC. The clinicopathological features of patients diagnosed with CHCC at Severance Hospital between January 1996 and December 2007 were retrospectively studied by comparing them with the features of patients with hepatocellular carcinoma (HCC) or cholangiocarcinoma (CC) who had undergone a hepatic resection during the same period. Forty-three patients diagnosed with CHCC were included in this study (M : F=35 : 8, median age, 55 years). According to the parameters of the American Joint Committee on Cancer staging, there were 6 (14.0%), 9 (20.9%), 25 (58.1%), and 3 (7.0%) patients with stages I, II, III, and IV cancer, respectively. Thirty-two of the 43 patients underwent resection with curative intent. After resection, 27 patients (84.4%) had tumor recurrence during the follow-up period of 18 months (range: 6-106 months), and the median time to recurrence was 13 months. Overall median survival periods after hepatic resection of CHCC, HCC and CC were 34, 103 and 38.9 months, respectively (p
ISSN:0513-5796
1976-2437
DOI:10.3349/ymj.2011.52.5.753