Overexpressions of Cyclin B1, cdc2, p16 and p53 in human breast cancer: the clinicopathologic correlations and prognostic implications

• Published in: Yonsei medical journal 2011, 52(3), , pp.445-453
• Main Authors: Chae, Seoung Wan, Sohn, Jin Hee, Kim, Dong-Hoon, Choi, Yoon Jung, Park, Yong Lai, Kim, Kyungeun, Cho, Young Hye, Pyo, Jung-Soo, Kim, Jun Ho
• Format: Article
• Language: English
• Subjects: Adult; Aged; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; CDC2 Protein Kinase; Cyclin B - genetics; Cyclin B - metabolism; Cyclin B1 - genetics; Cyclin B1 - metabolism; Cyclin-Dependent Kinase Inhibitor p16 - genetics; Cyclin-Dependent Kinase Inhibitor p16 - metabolism; Cyclin-Dependent Kinases; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Middle Aged; Original; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; 의학일반
• ISSN: 0513-5796; 1976-2437
• DOI: 10.3349/ymj.2011.52.3.445

The molecular mechanisms that are responsible for the initiation and progression of breast cancers are largely unknown. This study was to analyze the cyclin B1, cdc2, p53 and p16 tumor suppressor genes in human breast cancer. To investigate the role of cyclin B1, cdc2, p53 and p16 in the pathogenesis and progression of breast carcinomas, 98 cases of breast cancers were examined by immunohistochemical method. The correlations of cyclin B1, cdc2, p53 and p16 expression with various clinico-pathologic findings were analysed. In the normal breast tissues, cyclin B1, cdc2 and p16 were weakly expressed, while p53 was not expressed. On the other hand, cyclin B1, cdc2, p53 and p16 were overexpressed in breast cancer, showing correlation between the expression of cyclin B1 and cdc2 and breast cancers (p=0.00). The overexpressions of cdc2 and p16 were correlated with an infiltrative tumor border pattern and this was statistically significant (p