DNA Polymorphisms and Haplotypes of Apolipoprotein A5's Attribution to the Plasma Triglyceride Levels in Koreans

Purpose: Recent studies using human and mice reported that apolipoprotein A-V (APOA5) gene plays an important role in controlling triglyceride (TG) concentrations. The purpose of the present study was to investigate the correlation between single nucleotide polymorphisms (SNPs) and haplotypes in the...

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Bibliographic Details
Published in:Yonsei medical journal 2007, 48(4), , pp.609-618
Main Authors: 최정란, 남정모, 강대룡, 엄상미, 이혜진, 박찬미, 임진우, 장양수
Format: Article
Language:Korean
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의학일반
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Summary:Purpose: Recent studies using human and mice reported that apolipoprotein A-V (APOA5) gene plays an important role in controlling triglyceride (TG) concentrations. The purpose of the present study was to investigate the correlation between single nucleotide polymorphisms (SNPs) and haplotypes in the APOA5 gene and TG in subjects and to search for possible associations of the APOA5 gene variants and common haplotypes with hypertriglyceridemia (HTG). Materials and Methods: We examined the case-control subjects including 100 HTG patients and 243 unrelated healthy control. The genes were screened for SNPs by direct sequencing in 48 genetically unrelated individuals. Six SNPs (-1390C>T, -1020G>A, -3A>G, V150M, G182C and 1259T>C) were genotyped in case and control populations. Results: In this study, our results indicated a strong association between APOA5 SNP -3A>G and G182C and elevated TG levels (p
ISSN:0513-5796
1976-2437