Clinical significance of human papillomavirus genotyping

Cervical cancer is the fourth most common cancer in women worldwide, and the human papillomavirus (HPV) is the main causative agent for its development. HPV is a heterogeneous virus, and a persistent infection with a high-risk HPV contributes to the development of cancer. In recent decades, great ad...

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Bibliographic Details
Published in:Journal of gynecologic oncology 2016, 27(2), , pp.1-12
Main Authors: Choi, Youn Jin, Park, Jong Sup
Format: Article
Language:English
Subjects:
DNA, Viral - analysis
Early Detection of Cancer - methods
Female
Genome, Viral
Genotype
Humans
Papillomaviridae - classification
Papillomaviridae - genetics
Papillomavirus Infections - complications
Papillomavirus Infections - drug therapy
Papillomavirus Infections - virology
Papillomavirus Vaccines - therapeutic use
Review
Uterine Cervical Neoplasms - diagnosis
Uterine Cervical Neoplasms - drug therapy
Uterine Cervical Neoplasms - virology
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Summary:Cervical cancer is the fourth most common cancer in women worldwide, and the human papillomavirus (HPV) is the main causative agent for its development. HPV is a heterogeneous virus, and a persistent infection with a high-risk HPV contributes to the development of cancer. In recent decades, great advances have been made in understanding the molecular biology of HPV, and HPV's significance in cervical cancer prevention and management has received increased attention. In this review, we discuss the role of HPV genotyping in cervical cancer by addressing: clinically important issues in HPV virology; the current application of HPV genotyping in clinical medicine; and potential future uses for HPV genotyping.
ISSN:2005-0380
2005-0399
DOI:10.3802/jgo.2016.27.e21