Synchronous gynecologic malignancy and preliminary results of Lynch syndrome

Lynch syndrome is a hereditary cancer syndrome that increases the risks of colorectal and gynecologic malignancies such as endometrial and ovarian cancer. Studies have shown that mutations in mismatch repair genes (MSH2, MSH6, and MLH1) are associated with Lynch syndrome. The aim of our study was to...

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Published in:Journal of gynecologic oncology 2011, 22(4), , pp.233-238
Main Authors: Kim, Min Kyu, Song, Sang Yong, Do, In-Gu, Kim, Seo-Hee, Choi, Chel Hun, Kim, Tae-Joong, Lee, Jeong-Won, Bae, Duk-Soo, Kim, Byoung-Gie
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Language:English
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산부인과학
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Summary:Lynch syndrome is a hereditary cancer syndrome that increases the risks of colorectal and gynecologic malignancies such as endometrial and ovarian cancer. Studies have shown that mutations in mismatch repair genes (MSH2, MSH6, and MLH1) are associated with Lynch syndrome. The aim of our study was to estimate the value of MSH2, MSH6, and MLH1 immunohistochemistry based on family history in a Korean sample. Thirty six women with synchronous gynecologic tumors of endometrial and ovarian cancer were identified among patients being treated at our institution. Among them, 32 patients had tumor blocks (total 62 slides) available for analysis. According to a diagnostic algorithm, we performed immunohistochemistry analyses. Staining was scored based on intensity and proportion (negative or 0: intensity undetectable or minimal, proportion
ISSN:2005-0380
2005-0399
DOI:10.3802/jgo.2011.22.4.233