Prediction of a high-risk group based on postoperative nadir CA-125 levels in patients with advanced epithelial ovarian cancer

We aimed to determine the ideal cut-off of nadir serum CA-125 level for prediction of progression free survival. Among 267 patients who achieved complete remission after chemotherapy, the correlation between nadir CA-125 and progression free survival were compared among the subgroups classified acco...

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Published in:Journal of gynecologic oncology 2011, 22(4), , pp.269-274
Main Authors: Kang, Sokbom, Kim, Tae-Joong, Seo, Sang-Soo, Kim, Byoung-Gie, Bae, Duk-Soo, Park, Sang-Yoon
Format: Article
Language:English
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산부인과학
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Summary:We aimed to determine the ideal cut-off of nadir serum CA-125 level for prediction of progression free survival. Among 267 patients who achieved complete remission after chemotherapy, the correlation between nadir CA-125 and progression free survival were compared among the subgroups classified according to the distribution of CA-125. The diagnostic odds ratio and area under the receiver operator characteristics curve were compared at various cut-off points. The nadir CA-125 levels did not have prognostic value under 12 U/mL (to 75 percentile). In contrast, they were significantly correlated with progression free survival only when the CA-125 level was greater than 12, which was 75 percentile (p=0.034). In predicting progression free survival 18 U/mL showed a hazard ratio of 2.85 (95% confidence interval, 1.70 to 4.76; p
ISSN:2005-0380
2005-0399
DOI:10.3802/jgo.2011.22.4.269