Oxidative stress and hepatic injury induced in mice fed a Sarcocystis hirsuta cyst extract

We studied the toxic effects of a cyst extract fed to mice. Degenerative changes were found in mice gavage-fed fresh, frozen, and heat-treated cyst extract. There were increases in the levels of serum aspartate aminotransferase and alanine aminotransferase as well as hepatic and brain malondialdehyd...

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Published in:Journal of veterinary science (Suwŏn-si, Korea) 2018, 19(4), , pp.500-504
Main Authors: Sasani, Maryam, Nabavi, Reza, Hajinezhad, Mohammadreza, Hasanein, Parisa
Format: Article
Language:English
Subjects:
Alanine Transaminase - metabolism
Animals
Antioxidants - metabolism
Aspartate Aminotransferases - metabolism
Biomarkers - metabolism
Brain - metabolism
Lipid Peroxidation
Liver - metabolism
Liver - parasitology
Liver - pathology
Liver - physiopathology
Male
Mice
Original
Oxidative Stress
Sarcocystis - physiology
Sarcocystosis - metabolism
Sarcocystosis - parasitology
Sarcocystosis - pathology
Sarcocystosis - physiopathology
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Summary:We studied the toxic effects of a cyst extract fed to mice. Degenerative changes were found in mice gavage-fed fresh, frozen, and heat-treated cyst extract. There were increases in the levels of serum aspartate aminotransferase and alanine aminotransferase as well as hepatic and brain malondialdehyde (MDA) levels along with concomitant decreases in catalase (CAT) and superoxide dismutase (SOD) activities of mice receiving fresh and frozen extracts. Gavage feeding of heat-treated cyst extract had no effects on liver enzymes or brain MDA content, but the liver MDA level did increase. Mice in the heat-treated cyst group showed reduced CAT and SOD activities as well as increased hepatic MDA levels compared to those in the control group. These results indicate that an extract of cyst can induce oxidative stress and hepatic injury, even after heat treatment.
ISSN:1229-845X
1976-555X
DOI:10.4142/jvs.2018.19.4.500