Phytochemical and pharmacological screening of Sargassium vulgare from Suez Canal, Egypt

The current study investigates the phytochemical and pharmaceutical activities of Sargassium vulgare (SVE) collected from the Suez Canal. The prescreening using cytotoxicity was tested against hepatocellular carcinoma cell lines. Furthermore the SVE inhibit cell growth effectively with IC50 = 20.8 µ...

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Bibliographic Details
Published in:Food science and biotechnology 2018, 27(4), , pp.963-979
Main Authors: Shreadah, Mohamed A., El Moneam, Nehad M. Abd, Al-Assar, Samy A., Nabil-Adam, Asmaa
Format: Article
Language:English
Subjects:
antioxidant activity
Antioxidants
antiviral properties
Assaying
Canals
cell growth
cell lines
chemical constituents of plants
Chemistry
Chemistry and Materials Science
Cyclooxygenase-2
Cytotoxicity
Egypt
enzyme inhibition
Food Science
Hepatocellular carcinoma
hepatoma
Inflammation
Inhibition
inhibitory concentration 50
Interleukin 6
Kinases
Natural products
neoplasm cells
Nutrition
Pharmaceuticals
Pharmacology
Phytochemicals
Protein-tyrosine kinase
RNA-directed DNA polymerase
Screening
sphingosine
Sphingosine kinase
Toxicity testing
Tumor cell lines
Tumor necrosis factor
tumor necrosis factors
Tyrosine
식품과학
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Summary:The current study investigates the phytochemical and pharmaceutical activities of Sargassium vulgare (SVE) collected from the Suez Canal. The prescreening using cytotoxicity was tested against hepatocellular carcinoma cell lines. Furthermore the SVE inhibit cell growth effectively with IC50 = 20.8 µg/ml. The pharmacological studies revealed high antioxidant capacity at all examined concentrations. On the meantime, anticancer assay carried out using tyrosine kinase (PTK) and sphingosine kinase 1 inhibitor screening assays revealed inhibition with 75.73 and 80.01%; respectively. Furthermore, the anti-inflammatory profiling revealed that the activities against COX1, COX2, IL6 and TNF were 77.39, 88.35, 75.38 and 71.24%; respectively. Additionally, the anti-Alzheimer results showed high activity at 1 mg with 76.33%. Finally the antiviral activities using reverse transcriptase inhibition assay give 92.24%. Consequently, it can be easily conclude that the SVE collected from the Suez Canal are excellent source of natural products for nutritional and pharmaceutical applications.
ISSN:1226-7708
2092-6456
DOI:10.1007/s10068-018-0323-3