Crosslinked Polyphosphazene Nanospheres with Anticancer Quercetin: Synthesis, Spectroscopic, Thermal Properties, and Controlled Drug Release

In this study, novel cross-linked inorganic-organic hybrid polyphosphazene nanospheres were synthesized via self-assembly precipitation polymerization between hexachlorocyclotriphosphazene (HCCP) as a crosslinker molecule and anticancer featured quercetin (QCT). The technique used for synthesizing Q...

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Bibliographic Details
Published in:Macromolecular research 2018, 26(8), , pp.671-679
Main Authors: Örüm, Simge Metinoğlu, Demircioğlu, Yasemin Süzen
Format: Article
Language:English
Subjects:
Acriflavine
Cancer
Characterization and Evaluation of Materials
Chemical synthesis
Chemistry
Chemistry and Materials Science
Complex Fluids and Microfluidics
Controlled release
Crosslinking
Drug delivery systems
Fluorescence
Fourier transforms
Infrared analysis
Morphology
Nanochemistry
Nanospheres
Nanotechnology
Photon correlation spectroscopy
Physical Chemistry
Polymer Sciences
Reaction time
Self-assembly
Soft and Granular Matter
Thermodynamic properties
Thermogravimetric analysis
X-ray diffraction
고분자공학
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Summary:In this study, novel cross-linked inorganic-organic hybrid polyphosphazene nanospheres were synthesized via self-assembly precipitation polymerization between hexachlorocyclotriphosphazene (HCCP) as a crosslinker molecule and anticancer featured quercetin (QCT). The technique used for synthesizing QCT nanospheres is quite simple and rapid, and has some advantages like using just ultrasonic power. Furthermore, it does not require any surfactant or stabilizer. Growth of nanospheres and reaction time effect on the formation of QCT nanospheres were investigated. Quercetin and 4′,7-dihydroxyflavone were compared for the formation of nanospheres. The particle size of the spheres was determined to be approximately 434 nm by DLS (dynamic light scattering) measurements in 3 hours reaction time. The structure and morphology of synthesized QCT nanospheres were investigated by SEMEDX (scanning electron microscope) and XRD (X-ray diffractometer). The spectroscopic and thermal properties of cyclomatrix polyphosphazene QCT nanospheres were investigated by FTIR (Fourier transform infrared spectroscopy), UV-vis (ultraviolet-visible), fluorescence, and TGA (thermogravimetric analysis). Moreover, QCT nanospheres were used for controlled release of acriflavine which had been chosen as a model drug.
ISSN:1598-5032
2092-7673
DOI:10.1007/s13233-018-6092-2