Therapeutic Effects of Leuprorelin (Leuprolide Acetate) in Sexual Offenders with Paraphilia

This study examined the clinical effects of leuprolide acetate in sexual offenders with paraphilic disorders evaluated by means of objective psychiatric assessment. The subjects of this study were seven sexual offenders who were being treated by means of an injection for sexual impulse control by a...

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Bibliographic Details
Published in:Journal of Korean medical science 2018, 33(37), , pp.1-12
Main Authors: Choi, Jong Hyuk, Lee, Jae Woo, Lee, Jang Kyu, Jang, Soyeong, Yoo, Mi, Lee, Dae-Bo, Hong, Jeong-Won, Noh, Il Suk, Lim, Myung Ho
Format: Article
Language:English
Subjects:
Adult
Criminals
Diagnostic and Statistical Manual of Mental Disorders
Humans
Leuprolide
Middle Aged
Original
Paraphilic Disorders
Sex Offenses
의학일반
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Summary:This study examined the clinical effects of leuprolide acetate in sexual offenders with paraphilic disorders evaluated by means of objective psychiatric assessment. The subjects of this study were seven sexual offenders who were being treated by means of an injection for sexual impulse control by a court order. They had been diagnosed with paraphilia by a psychiatrist based on the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) and had been put on probation by the Ministry of Justice between January 2016 and December 2016. After twelve months, we observed significant improvement in symptoms, as decrease of abnormal sexual interest and activity, sexual fantasy, Clinical Global Impression-Severity (CGI-S), and Clinical Global Impression-Impulsivity (GCI-I). There were a mild feminization of the body shape, feelings of fatigue, and mild hot flushes. No other adverse effect was reported. These results suggested that the clinical effects of leuprolide acetate in sexual offenders might be an effective treatment and safety strategy.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2018.33.e231