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Therapeutic Effects of Leuprorelin (Leuprolide Acetate) in Sexual Offenders with Paraphilia
This study examined the clinical effects of leuprolide acetate in sexual offenders with paraphilic disorders evaluated by means of objective psychiatric assessment. The subjects of this study were seven sexual offenders who were being treated by means of an injection for sexual impulse control by a...
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| Published in: | Journal of Korean medical science 2018, 33(37), , pp.1-12 |
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| Main Authors: | , , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c433t-bc3c1d99965cc6bc8e26c0ae167407385b24ddd9e56467f64818ab3e148922c93 |
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| cites | cdi_FETCH-LOGICAL-c433t-bc3c1d99965cc6bc8e26c0ae167407385b24ddd9e56467f64818ab3e148922c93 |
| container_end_page | e231 |
| container_issue | 37 |
| container_start_page | e231 |
| container_title | Journal of Korean medical science |
| container_volume | 33 |
| creator | Choi, Jong Hyuk Lee, Jae Woo Lee, Jang Kyu Jang, Soyeong Yoo, Mi Lee, Dae-Bo Hong, Jeong-Won Noh, Il Suk Lim, Myung Ho |
| description | This study examined the clinical effects of leuprolide acetate in sexual offenders with paraphilic disorders evaluated by means of objective psychiatric assessment.
The subjects of this study were seven sexual offenders who were being treated by means of an injection for sexual impulse control by a court order. They had been diagnosed with paraphilia by a psychiatrist based on the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) and had been put on probation by the Ministry of Justice between January 2016 and December 2016.
After twelve months, we observed significant improvement in symptoms, as decrease of abnormal sexual interest and activity, sexual fantasy, Clinical Global Impression-Severity (CGI-S), and Clinical Global Impression-Impulsivity (GCI-I). There were a mild feminization of the body shape, feelings of fatigue, and mild hot flushes. No other adverse effect was reported.
These results suggested that the clinical effects of leuprolide acetate in sexual offenders might be an effective treatment and safety strategy. |
| doi_str_mv | 10.3346/jkms.2018.33.e231 |
| format | article |
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The subjects of this study were seven sexual offenders who were being treated by means of an injection for sexual impulse control by a court order. They had been diagnosed with paraphilia by a psychiatrist based on the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) and had been put on probation by the Ministry of Justice between January 2016 and December 2016.
After twelve months, we observed significant improvement in symptoms, as decrease of abnormal sexual interest and activity, sexual fantasy, Clinical Global Impression-Severity (CGI-S), and Clinical Global Impression-Impulsivity (GCI-I). There were a mild feminization of the body shape, feelings of fatigue, and mild hot flushes. No other adverse effect was reported.
These results suggested that the clinical effects of leuprolide acetate in sexual offenders might be an effective treatment and safety strategy.</description><identifier>ISSN: 1011-8934</identifier><identifier>EISSN: 1598-6357</identifier><identifier>DOI: 10.3346/jkms.2018.33.e231</identifier><identifier>PMID: 30190656</identifier><language>eng</language><publisher>Korea (South): The Korean Academy of Medical Sciences</publisher><subject>Adult ; Criminals ; Diagnostic and Statistical Manual of Mental Disorders ; Humans ; Leuprolide ; Middle Aged ; Original ; Paraphilic Disorders ; Sex Offenses ; 의학일반</subject><ispartof>Journal of Korean Medical Science, 2018, 33(37), , pp.1-12</ispartof><rights>2018 The Korean Academy of Medical Sciences. 2018 The Korean Academy of Medical Sciences</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-bc3c1d99965cc6bc8e26c0ae167407385b24ddd9e56467f64818ab3e148922c93</citedby><cites>FETCH-LOGICAL-c433t-bc3c1d99965cc6bc8e26c0ae167407385b24ddd9e56467f64818ab3e148922c93</cites><orcidid>0000-0002-4927-4286 ; 0000-0003-0778-4445 ; 0000-0002-9163-2139 ; 0000-0002-0301-8834 ; 0000-0003-1113-2781 ; 0000-0003-0367-8311 ; 0000-0001-5370-4376 ; 0000-0003-0951-4051 ; 0000-0001-7603-5099</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125314/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125314/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30190656$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002383770$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Jong Hyuk</creatorcontrib><creatorcontrib>Lee, Jae Woo</creatorcontrib><creatorcontrib>Lee, Jang Kyu</creatorcontrib><creatorcontrib>Jang, Soyeong</creatorcontrib><creatorcontrib>Yoo, Mi</creatorcontrib><creatorcontrib>Lee, Dae-Bo</creatorcontrib><creatorcontrib>Hong, Jeong-Won</creatorcontrib><creatorcontrib>Noh, Il Suk</creatorcontrib><creatorcontrib>Lim, Myung Ho</creatorcontrib><title>Therapeutic Effects of Leuprorelin (Leuprolide Acetate) in Sexual Offenders with Paraphilia</title><title>Journal of Korean medical science</title><addtitle>J Korean Med Sci</addtitle><description>This study examined the clinical effects of leuprolide acetate in sexual offenders with paraphilic disorders evaluated by means of objective psychiatric assessment.
The subjects of this study were seven sexual offenders who were being treated by means of an injection for sexual impulse control by a court order. They had been diagnosed with paraphilia by a psychiatrist based on the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) and had been put on probation by the Ministry of Justice between January 2016 and December 2016.
After twelve months, we observed significant improvement in symptoms, as decrease of abnormal sexual interest and activity, sexual fantasy, Clinical Global Impression-Severity (CGI-S), and Clinical Global Impression-Impulsivity (GCI-I). There were a mild feminization of the body shape, feelings of fatigue, and mild hot flushes. No other adverse effect was reported.
These results suggested that the clinical effects of leuprolide acetate in sexual offenders might be an effective treatment and safety strategy.</description><subject>Adult</subject><subject>Criminals</subject><subject>Diagnostic and Statistical Manual of Mental Disorders</subject><subject>Humans</subject><subject>Leuprolide</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Paraphilic Disorders</subject><subject>Sex Offenses</subject><subject>의학일반</subject><issn>1011-8934</issn><issn>1598-6357</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpVkc1O3DAUhS1UBJT2AdhUXsIiU__H3lQaIWiRRgLBdNWF5Tg3jJlMMtgJtG9fh6GIrq6Pfc5nywehE0pmnAv19WG9STNGqM5yBozTPXREpdGF4rL8kNeE0kIbLg7Rx5QeCGFSMn6ADjmhhiipjtCv5Qqi28I4BI8vmgb8kHDf4AWM29hHaEOHT3eiDTXguYfBDXCG8_4d_B5di69zqqshJvwchhW-cZm3Cm1wn9B-49oEn1_nMfp5ebE8_1Esrr9fnc8XhRecD0Xluae1MUZJ71XlNTDliQOqSkFKrmXFRF3XBqQSqmyU0FS7igMV2jDmDT9GZztuFxu79sH2LrzM-96uo53fLq8sLxUVdPJ-23m3Y7WB2kM3RNfabQwbF_-8JP8_6cIqc56sokxyKjLg9BUQ-8cR0mA3IXloW9dBPybL8qezUhGms5XurD72KUVo3q6hxE4F2qlAOxWYpZ0KzJkv79_3lvjXGP8LSsiYXA</recordid><startdate>20180910</startdate><enddate>20180910</enddate><creator>Choi, Jong Hyuk</creator><creator>Lee, Jae Woo</creator><creator>Lee, Jang Kyu</creator><creator>Jang, Soyeong</creator><creator>Yoo, Mi</creator><creator>Lee, Dae-Bo</creator><creator>Hong, Jeong-Won</creator><creator>Noh, Il Suk</creator><creator>Lim, Myung Ho</creator><general>The Korean Academy of Medical Sciences</general><general>대한의학회</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>ACYCR</scope><orcidid>https://orcid.org/0000-0002-4927-4286</orcidid><orcidid>https://orcid.org/0000-0003-0778-4445</orcidid><orcidid>https://orcid.org/0000-0002-9163-2139</orcidid><orcidid>https://orcid.org/0000-0002-0301-8834</orcidid><orcidid>https://orcid.org/0000-0003-1113-2781</orcidid><orcidid>https://orcid.org/0000-0003-0367-8311</orcidid><orcidid>https://orcid.org/0000-0001-5370-4376</orcidid><orcidid>https://orcid.org/0000-0003-0951-4051</orcidid><orcidid>https://orcid.org/0000-0001-7603-5099</orcidid></search><sort><creationdate>20180910</creationdate><title>Therapeutic Effects of Leuprorelin (Leuprolide Acetate) in Sexual Offenders with Paraphilia</title><author>Choi, Jong Hyuk ; Lee, Jae Woo ; Lee, Jang Kyu ; Jang, Soyeong ; Yoo, Mi ; Lee, Dae-Bo ; Hong, Jeong-Won ; Noh, Il Suk ; Lim, Myung Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-bc3c1d99965cc6bc8e26c0ae167407385b24ddd9e56467f64818ab3e148922c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Criminals</topic><topic>Diagnostic and Statistical Manual of Mental Disorders</topic><topic>Humans</topic><topic>Leuprolide</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Paraphilic Disorders</topic><topic>Sex Offenses</topic><topic>의학일반</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Jong Hyuk</creatorcontrib><creatorcontrib>Lee, Jae Woo</creatorcontrib><creatorcontrib>Lee, Jang Kyu</creatorcontrib><creatorcontrib>Jang, Soyeong</creatorcontrib><creatorcontrib>Yoo, Mi</creatorcontrib><creatorcontrib>Lee, Dae-Bo</creatorcontrib><creatorcontrib>Hong, Jeong-Won</creatorcontrib><creatorcontrib>Noh, Il Suk</creatorcontrib><creatorcontrib>Lim, Myung Ho</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Korean Citation Index</collection><jtitle>Journal of Korean medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Jong Hyuk</au><au>Lee, Jae Woo</au><au>Lee, Jang Kyu</au><au>Jang, Soyeong</au><au>Yoo, Mi</au><au>Lee, Dae-Bo</au><au>Hong, Jeong-Won</au><au>Noh, Il Suk</au><au>Lim, Myung Ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic Effects of Leuprorelin (Leuprolide Acetate) in Sexual Offenders with Paraphilia</atitle><jtitle>Journal of Korean medical science</jtitle><addtitle>J Korean Med Sci</addtitle><date>2018-09-10</date><risdate>2018</risdate><volume>33</volume><issue>37</issue><spage>e231</spage><epage>e231</epage><pages>e231-e231</pages><issn>1011-8934</issn><eissn>1598-6357</eissn><abstract>This study examined the clinical effects of leuprolide acetate in sexual offenders with paraphilic disorders evaluated by means of objective psychiatric assessment.
The subjects of this study were seven sexual offenders who were being treated by means of an injection for sexual impulse control by a court order. They had been diagnosed with paraphilia by a psychiatrist based on the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) and had been put on probation by the Ministry of Justice between January 2016 and December 2016.
After twelve months, we observed significant improvement in symptoms, as decrease of abnormal sexual interest and activity, sexual fantasy, Clinical Global Impression-Severity (CGI-S), and Clinical Global Impression-Impulsivity (GCI-I). There were a mild feminization of the body shape, feelings of fatigue, and mild hot flushes. No other adverse effect was reported.
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| ispartof | Journal of Korean Medical Science, 2018, 33(37), , pp.1-12 |
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| language | eng |
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| subjects | Adult Criminals Diagnostic and Statistical Manual of Mental Disorders Humans Leuprolide Middle Aged Original Paraphilic Disorders Sex Offenses 의학일반 |
| title | Therapeutic Effects of Leuprorelin (Leuprolide Acetate) in Sexual Offenders with Paraphilia |
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