The effect of calcium gluconate with natural extracts on skin toxicity of hydrofluoric acid

Backgrounds Hydrofluoric acid (HF) is a highly corrosive acid. The conventional treatment for HF burn is topical application of calcium gluconate (CG). Our study aimed to assess the synergistic effects of natural extracts ( Centella asiatica, Portulaca oleracea , and blueberry extracts) in combinati...

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Bibliographic Details
Published in:Molecular & cellular toxicology 2018, 14(4), , pp.381-389
Main Authors: Shin, Jung Jin, Lee, Hana, Jeong, Sang Hoon, Kim, Ji Hyun, Lee, Myungjin, Son, Sang Wook
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Calcium
Cell Biology
Cell proliferation
Chemical industry
Collagen
Flavors
Life Sciences
Original Paper
Pharmacology/Toxicology
Polymerase chain reaction
Reverse transcription
Skin
Topical application
Toxicity
Wound healing
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Summary:Backgrounds Hydrofluoric acid (HF) is a highly corrosive acid. The conventional treatment for HF burn is topical application of calcium gluconate (CG). Our study aimed to assess the synergistic effects of natural extracts ( Centella asiatica, Portulaca oleracea , and blueberry extracts) in combination with CG in healing HF induced burn wound. Methods We investigated the effects of different topical CG formulations with natural extracts using cell proliferation assay, western blot, reverse transcription- polymerase chain reaction, human skin equivalent model (HSEM), and mouse model. Results Topical CG formulations with natural extracts showed better recovery from HF burns shown by greater collagen expression in the dermal fibroblast model, HSEM and mouse model. Conclusion Our study demonstrated that CG in combination with natural extracts show superior wound healing in treating HF burn compared to CG monotherapy.
ISSN:1738-642X
2092-8467
DOI:10.1007/s13273-018-0042-0