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A carboxymethyl dextran-based polymeric conjugate as the antigen carrier for cancer immunotherapy
Antigen-specific cytotoxic T lymphocytes (CTLs), which eliminate target cells bearing antigenic peptides presented by surface major histocompatibility complex (MHC) class I molecules, play a key role in cancer immunotherapy. However, the majority of tumors are not immunologically rejected since they...
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| Published in: | Biomaterials research 2018, 22(3), , pp.195-201 |
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| Main Authors: | , , , , , |
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| cites | cdi_FETCH-LOGICAL-c5800-9e4bfa0e40331e778dd78cff7adf7d9311f2a51a4d52d8d1accc4a0bfff697f33 |
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| container_title | Biomaterials research |
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| creator | Shin, Jung Min Song, Seok Ho Vijayakameswara Rao, N Lee, Eun Sook Ko, Hyewon Park, Jae Hyung |
| description | Antigen-specific cytotoxic T lymphocytes (CTLs), which eliminate target cells bearing antigenic peptides presented by surface major histocompatibility complex (MHC) class I molecules, play a key role in cancer immunotherapy. However, the majority of tumors are not immunologically rejected since they express self-antigens which are not recognized by CTLs as foreign. To foreignize these tumors for CTL-mediated immunological rejection, it is essential to develop carriers that can effectively deliver foreign antigens to cancer cells.
A polymeric conjugate, composed of a carboxymethyl dextran (CMD) as the backbone and ovalbumin (OVA) as a model foreign antigen, was prepared to investigate its potential as the antigen carrier for cancer immunotherapy.
An in vitro cellular uptake study showed that the conjugate was successfully taken up by TC-1 cervical cancer cells. When CMD-OVA was systemically administered to tumor-bearing mice, the strong fluorescence signal was observed at the tumor site over the whole period of time period, suggesting high tumor targetability of the conjugate. Compared to free OVA, CMD-OVA induced significantly higher antigen presentation at the tumor site.
The CMD-OVA conjugate can effectively deliver the antigen to the tumor site, implying its high potential as the antigen carrier for cancer immunotherapy. |
| doi_str_mv | 10.1186/s40824-018-0131-0 |
| format | article |
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A polymeric conjugate, composed of a carboxymethyl dextran (CMD) as the backbone and ovalbumin (OVA) as a model foreign antigen, was prepared to investigate its potential as the antigen carrier for cancer immunotherapy.
An in vitro cellular uptake study showed that the conjugate was successfully taken up by TC-1 cervical cancer cells. When CMD-OVA was systemically administered to tumor-bearing mice, the strong fluorescence signal was observed at the tumor site over the whole period of time period, suggesting high tumor targetability of the conjugate. Compared to free OVA, CMD-OVA induced significantly higher antigen presentation at the tumor site.
The CMD-OVA conjugate can effectively deliver the antigen to the tumor site, implying its high potential as the antigen carrier for cancer immunotherapy.</description><identifier>ISSN: 1226-4601</identifier><identifier>ISSN: 2055-7124</identifier><identifier>EISSN: 2055-7124</identifier><identifier>DOI: 10.1186/s40824-018-0131-0</identifier><identifier>PMID: 30128166</identifier><language>eng</language><publisher>United States: BioMed Central Ltd</publisher><subject>Antigen delivery ; Antigen presentation ; Autoantigens ; Biomedical materials ; Cancer ; Cancer immunotherapy ; Cancer therapies ; Carboxymethyl cellulose ; Carboxymethyl dextran ; Care and treatment ; Cervical cancer ; Cervix ; Chemical properties ; Clinical trials ; Cytotoxicity ; Dextran ; Immunology ; Immunotherapy ; Lymphocytes ; Lymphocytes T ; Major histocompatibility complex ; Microscopy ; Ovalbumin ; Tumors ; 의공학</subject><ispartof>생체재료학회지, 2018, 22(3), , pp.195-201</ispartof><rights>COPYRIGHT 2018 BioMed Central Ltd.</rights><rights>Copyright © 2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s). 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5800-9e4bfa0e40331e778dd78cff7adf7d9311f2a51a4d52d8d1accc4a0bfff697f33</citedby><cites>FETCH-LOGICAL-c5800-9e4bfa0e40331e778dd78cff7adf7d9311f2a51a4d52d8d1accc4a0bfff697f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092827/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2089729211?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25751,27922,27923,37010,37011,44588,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30128166$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002391228$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Shin, Jung Min</creatorcontrib><creatorcontrib>Song, Seok Ho</creatorcontrib><creatorcontrib>Vijayakameswara Rao, N</creatorcontrib><creatorcontrib>Lee, Eun Sook</creatorcontrib><creatorcontrib>Ko, Hyewon</creatorcontrib><creatorcontrib>Park, Jae Hyung</creatorcontrib><title>A carboxymethyl dextran-based polymeric conjugate as the antigen carrier for cancer immunotherapy</title><title>Biomaterials research</title><addtitle>Biomater Res</addtitle><description>Antigen-specific cytotoxic T lymphocytes (CTLs), which eliminate target cells bearing antigenic peptides presented by surface major histocompatibility complex (MHC) class I molecules, play a key role in cancer immunotherapy. However, the majority of tumors are not immunologically rejected since they express self-antigens which are not recognized by CTLs as foreign. To foreignize these tumors for CTL-mediated immunological rejection, it is essential to develop carriers that can effectively deliver foreign antigens to cancer cells.
A polymeric conjugate, composed of a carboxymethyl dextran (CMD) as the backbone and ovalbumin (OVA) as a model foreign antigen, was prepared to investigate its potential as the antigen carrier for cancer immunotherapy.
An in vitro cellular uptake study showed that the conjugate was successfully taken up by TC-1 cervical cancer cells. When CMD-OVA was systemically administered to tumor-bearing mice, the strong fluorescence signal was observed at the tumor site over the whole period of time period, suggesting high tumor targetability of the conjugate. Compared to free OVA, CMD-OVA induced significantly higher antigen presentation at the tumor site.
The CMD-OVA conjugate can effectively deliver the antigen to the tumor site, implying its high potential as the antigen carrier for cancer immunotherapy.</description><subject>Antigen delivery</subject><subject>Antigen presentation</subject><subject>Autoantigens</subject><subject>Biomedical materials</subject><subject>Cancer</subject><subject>Cancer immunotherapy</subject><subject>Cancer therapies</subject><subject>Carboxymethyl cellulose</subject><subject>Carboxymethyl dextran</subject><subject>Care and treatment</subject><subject>Cervical cancer</subject><subject>Cervix</subject><subject>Chemical properties</subject><subject>Clinical trials</subject><subject>Cytotoxicity</subject><subject>Dextran</subject><subject>Immunology</subject><subject>Immunotherapy</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Major histocompatibility complex</subject><subject>Microscopy</subject><subject>Ovalbumin</subject><subject>Tumors</subject><subject>의공학</subject><issn>1226-4601</issn><issn>2055-7124</issn><issn>2055-7124</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkl1r2zAYhc3YWEPXH7CbYdjNeuFOX7akm0Eo-wgUBl13LV7rI1FqW5lkj-bfT066bhnDmFdIzzm2j09RvMboCmPRvE8MCcIqhEW-Ka7Qs2JBUF1XHBP2vFhgQpqKNQifFRcpbRFCmGHJavmyOKMIE4GbZlHAstQQ2_Cw7-242XelsQ9jhKFqIVlT7kKXD6LXpQ7DdlrDaEtI5bjJYxj92g6zPHobSxdiXg86L33fT0PIUITd_lXxwkGX7MXjPC--f_p4d_2luvn6eXW9vKl0LRCqpGWtA2QZohRbzoUxXGjnOBjHjaQYOwI1BmZqYoTBoLVmgFrnXCO5o_S8uDz6DtGpe-1VAH-Y66Duo1re3q0U5Y3IIWR2dWRNgK3aRd9D3B8Eh40Q1wri6HVnFYUcFG55w61gLQfpHEhKEUjkNNFN9vpw9NpNbW-NtkPOrzsxPT0Z_Ca_00_VIEkE4dng3aNBDD8mm0bV-6Rt18Fgw5QUQRITyqSY0bf_oNswxSHHmikhOZEE4z_UGvIH-MGF_Fw9m6plXTdScibmvK7-Q-XL2N7nv22dz_sngssTQWbGXJY1TCmp1bfbUxYfWR1DStG6pzwwUnN91bG-KtdXzfVVKGve_B3kk-J3WekvGfzprg</recordid><startdate>20180814</startdate><enddate>20180814</enddate><creator>Shin, Jung Min</creator><creator>Song, Seok Ho</creator><creator>Vijayakameswara Rao, N</creator><creator>Lee, Eun Sook</creator><creator>Ko, Hyewon</creator><creator>Park, Jae Hyung</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>American Association for the Advancement of Science (AAAS)</general><general>한국생체재료학회</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><scope>ACYCR</scope></search><sort><creationdate>20180814</creationdate><title>A carboxymethyl dextran-based polymeric conjugate as the antigen carrier for cancer immunotherapy</title><author>Shin, Jung Min ; Song, Seok Ho ; Vijayakameswara Rao, N ; Lee, Eun Sook ; Ko, Hyewon ; Park, Jae Hyung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5800-9e4bfa0e40331e778dd78cff7adf7d9311f2a51a4d52d8d1accc4a0bfff697f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Antigen delivery</topic><topic>Antigen presentation</topic><topic>Autoantigens</topic><topic>Biomedical materials</topic><topic>Cancer</topic><topic>Cancer immunotherapy</topic><topic>Cancer therapies</topic><topic>Carboxymethyl cellulose</topic><topic>Carboxymethyl dextran</topic><topic>Care and treatment</topic><topic>Cervical cancer</topic><topic>Cervix</topic><topic>Chemical properties</topic><topic>Clinical trials</topic><topic>Cytotoxicity</topic><topic>Dextran</topic><topic>Immunology</topic><topic>Immunotherapy</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Major histocompatibility complex</topic><topic>Microscopy</topic><topic>Ovalbumin</topic><topic>Tumors</topic><topic>의공학</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shin, Jung Min</creatorcontrib><creatorcontrib>Song, Seok Ho</creatorcontrib><creatorcontrib>Vijayakameswara Rao, N</creatorcontrib><creatorcontrib>Lee, Eun Sook</creatorcontrib><creatorcontrib>Ko, Hyewon</creatorcontrib><creatorcontrib>Park, Jae Hyung</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><collection>Korean Citation Index (Open Access)</collection><jtitle>Biomaterials research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shin, Jung Min</au><au>Song, Seok Ho</au><au>Vijayakameswara Rao, N</au><au>Lee, Eun Sook</au><au>Ko, Hyewon</au><au>Park, Jae Hyung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A carboxymethyl dextran-based polymeric conjugate as the antigen carrier for cancer immunotherapy</atitle><jtitle>Biomaterials research</jtitle><addtitle>Biomater Res</addtitle><date>2018-08-14</date><risdate>2018</risdate><volume>22</volume><issue>1</issue><spage>21</spage><epage>21</epage><pages>21-21</pages><issn>1226-4601</issn><issn>2055-7124</issn><eissn>2055-7124</eissn><abstract>Antigen-specific cytotoxic T lymphocytes (CTLs), which eliminate target cells bearing antigenic peptides presented by surface major histocompatibility complex (MHC) class I molecules, play a key role in cancer immunotherapy. However, the majority of tumors are not immunologically rejected since they express self-antigens which are not recognized by CTLs as foreign. To foreignize these tumors for CTL-mediated immunological rejection, it is essential to develop carriers that can effectively deliver foreign antigens to cancer cells.
A polymeric conjugate, composed of a carboxymethyl dextran (CMD) as the backbone and ovalbumin (OVA) as a model foreign antigen, was prepared to investigate its potential as the antigen carrier for cancer immunotherapy.
An in vitro cellular uptake study showed that the conjugate was successfully taken up by TC-1 cervical cancer cells. When CMD-OVA was systemically administered to tumor-bearing mice, the strong fluorescence signal was observed at the tumor site over the whole period of time period, suggesting high tumor targetability of the conjugate. Compared to free OVA, CMD-OVA induced significantly higher antigen presentation at the tumor site.
The CMD-OVA conjugate can effectively deliver the antigen to the tumor site, implying its high potential as the antigen carrier for cancer immunotherapy.</abstract><cop>United States</cop><pub>BioMed Central Ltd</pub><pmid>30128166</pmid><doi>10.1186/s40824-018-0131-0</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antigen delivery Antigen presentation Autoantigens Biomedical materials Cancer Cancer immunotherapy Cancer therapies Carboxymethyl cellulose Carboxymethyl dextran Care and treatment Cervical cancer Cervix Chemical properties Clinical trials Cytotoxicity Dextran Immunology Immunotherapy Lymphocytes Lymphocytes T Major histocompatibility complex Microscopy Ovalbumin Tumors 의공학 |
| title | A carboxymethyl dextran-based polymeric conjugate as the antigen carrier for cancer immunotherapy |
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