Treadmill exercise improves memory function by inhibiting hippocampal apoptosis in pilocarpine-induced epileptic rats

Epilepsy is characterized by recurrent seizures and loss of neurons with abnormal rhythmic firing in the brains. In the present study, we investi-gated the effect of treadmill exercise on memory function in relation with cell proliferation and apoptosis in the hippocampus using pilocar-pine-induced...

Full description

Saved in:
Bibliographic Details
Published in:Journal of exercise rehabilitation 2018, 14(5), 57, pp.713-723
Main Authors: Lee, Jae-Min, Ji, Eun-Sang, Kim, Tae-Woon, Kim, Chang-Ju, Shin, Mal-Soon, Lim, Baek-Vin, Chung, Yong-Rak, Cho, Young Sam
Format: Article
Language:English
Subjects:
Original
심리과학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Epilepsy is characterized by recurrent seizures and loss of neurons with abnormal rhythmic firing in the brains. In the present study, we investi-gated the effect of treadmill exercise on memory function in relation with cell proliferation and apoptosis in the hippocampus using pilocar-pine-induced seizure rats. Epilepsy was initiated by intraperitoneal in-jection of pilocarpine hydrochloride. The rats in the exercise group were forced to run on a motorized treadmill for 30 min once a day for 2 weeks. In the present results, treadmill exercise alleviated short-term and spatial learning memory impairments in the epileptic rats. Treadmill exercise suppressed neuronal degeneration and enhanced neuronal maturation in the epileptic rats. Treadmill exercise suppressed cell pro-liferation and apoptosis in the epileptic rats. Treadmill exercise alleviat-ed pilocarpine-induced memory impairments and suppressed neuronal loss in the hippocampus through down-regulation of apoptosis. These findings offer a possibility that treadmill exercise may provide a preven-tive or therapeutic value to the epilepsy-induced learning and memory impairments.
ISSN:2288-176X
2288-1778
DOI:10.12965/jer.36394.197