Denosumab for Treatment of a Recurrent Cervical Giant-Cell Tumor

A 43-year-old male patient with C5 giant cell tumor (GCT) underwent tumor resection and anterior bone fusion of C4-C6. The tumor recurred locally 9 months after surgery with the patient complaining of neck and shoulder pain similar to his preoperative symptoms. Denosumab was administered and his pai...

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Bibliographic Details
Published in:Asian spine journal 2016, 10(3), , pp.553-557
Main Authors: Kajiwara, Daisuke, Kamoda, Hiroto, Yonemoto, Tsukasa, Iwata, Shintaro, Ishii, Takeshi, Tsukanishi, Toshinori, Ohtori, Seiji, Yamazaki, Masashi, Okawa, Akihiko
Format: Article
Language:English
Subjects:
Bone tumors
Case Report
Cervical vertebrae
Computed tomography
Conflicts of interest
Denosumab
Fibroblasts
Fractures
Giant cell tumor of bone
Hypocalcemia
Magnetic resonance imaging
Neck pain
Pain
Patients
Recurrence
Skin & tissue grafts
Spine (cervical)
Surgery
Tomography
Tumors
정형외과학
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Summary:A 43-year-old male patient with C5 giant cell tumor (GCT) underwent tumor resection and anterior bone fusion of C4-C6. The tumor recurred locally 9 months after surgery with the patient complaining of neck and shoulder pain similar to his preoperative symptoms. Denosumab was administered and his pain disappeared after a two-month administration, with a sclerotic rim formation seen at the tumor site on computed tomography. He has been followed for 18 months with no evidence of tumor recurrence. Complete resection is generally recommended, but is not easy for many patients with cervical GCT because of the existence of neurovascular structures. Some patients suffer from recurrence and treatment becomes more difficult. As such, denosumab may be an efficacious option for treatment of recurrent GCT of the cervical spine, although long-term follow-up is required to monitor for presence or absence of recurrence.
ISSN:1976-1902
1976-7846
DOI:10.4184/asj.2016.10.3.553