Effects of Atorvastatin in Patients with Acute Spinal Cord Injury

Clinical trial study. The aim of this study was to evaluate the effect of atorvastatin on sensory and motor function in patients with acute spinal cord injury. The prevalence and incidence of traumatic spinal cord injury are increasing. Statins are well established for use in hypercholesterolemia as...

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Bibliographic Details
Published in:Asian spine journal 2017, 11(6), , pp.903-907
Main Authors: Aghazadeh, Javad, Samadi Motlagh, Parviz, Salehpour, Firooz, Meshkini, Ali, Fatehi, Majid, Mirzaei, Farhad, Naseri Alavi, Seyed Ahmad
Format: Article
Language:English
Subjects:
Atorvastatin
Clinical Study
Clinical trials
Hypercholesterolemia
Inflammation
Pain
Patients
Spinal cord injuries
Standard deviation
Statins
Trauma
Tumor necrosis factor-TNF
Wound and injuries
정형외과학
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Summary:Clinical trial study. The aim of this study was to evaluate the effect of atorvastatin on sensory and motor function in patients with acute spinal cord injury. The prevalence and incidence of traumatic spinal cord injury are increasing. Statins are well established for use in hypercholesterolemia as well as during anti-inflammatory events. This clinical trial study included 60 patients with acute spinal cord injury. These were randomly divided into two groups: the case group which received atorvastatin and also underwent surgical therapy and the control group which only underwent surgical therapy. The severity of spinal cord lesions was evaluated based on the Frankel grade at three periods; this showed no significant difference between the two groups. Comparisons of the levels of pain between the groups based on a Visual Analog Scale system showed no significant difference at the three periods. We observed no improvement at the 3- and 6-month follow-up in patients who were administered atorvastatin. However, a comparison of the two groups based on pain severity demonstrated a significant difference, suggesting that atorvastatin had a positive effect on patients with spinal cord injury.
ISSN:1976-1902
1976-7846
DOI:10.4184/asj.2017.11.6.903