Brain Theranostics and Radiotheranostics: Exosomes and Graphenes In Vivo as Novel Brain Theranostics

Brain disease is one of the greatest threats to public health. Brain theranostics is recently taking shape, indicating the treatments of stroke, inflammatory brain disorders, psychiatric diseases, neurodevelopmental disease, and neurodegenerative disease. However, several factors, such as lack of en...

Full description

Saved in:
Bibliographic Details
Published in:Nuclear medicine and molecular imaging 2018, 52(6), , pp.407-419
Main Authors: Suh, Minseok, Lee, Dong Soo
Format: Article
Language:English
Subjects:
Blood-brain barrier
Brain
Cardiology
Disease
Graphene
Imaging
Medicine
Medicine & Public Health
Nuclear Medicine
Oncology
Orthopedics
Public health
Quantum dots
Radiology
Review
방사선과학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Brain disease is one of the greatest threats to public health. Brain theranostics is recently taking shape, indicating the treatments of stroke, inflammatory brain disorders, psychiatric diseases, neurodevelopmental disease, and neurodegenerative disease. However, several factors, such as lack of endophenotype classification, blood-brain barrier (BBB), target determination, ignorance of biodistribution after administration, and complex intercellular communication between brain cells, make brain theranostics application difficult, especially when it comes to clinical application. So, a more thorough understanding of each aspect is needed. In this review, we focus on recent studies regarding the role of exosomes in intercellular communication of brain cells, therapeutic effect of graphene quantum dots, transcriptomics/epitranscriptomics approach for target selection, and in vitro/in vivo considerations.
ISSN:1869-3474
1869-3482
DOI:10.1007/s13139-018-0550-9