Probiotics as a Potential Immunomodulating Pharmabiotics in Allergic Diseases: Current Status and Future Prospects

The prevalence of allergic disorders has dramatically increased over the past decade, particularly in developed countries. Apart from gastrointestinal disorders, neoplasia, genital and dermatological diseases , dysregulation of gut microbiota (dysbiosis) has also been found to be associated with inc...

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Bibliographic Details
Published in:Allergy, asthma & immunology research 2018, Asthma & Immunology Research, 10(6), , pp.575-590
Main Authors: Sharma, Garima, Im, Sin Hyeog
Format: Article
Language:English
Subjects:
Allergic diseases
Allergies
Asthma
Atopic dermatitis
Dermatitis
Developed countries
Disorders
Dysbacteriosis
Food
Food allergies
Food habits
Food preferences
Gastrointestinal diseases
Guidelines
Immunomodulation
Intestinal microflora
Metabolites
Microbiota
Probiotics
Quality assurance
Review
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Summary:The prevalence of allergic disorders has dramatically increased over the past decade, particularly in developed countries. Apart from gastrointestinal disorders, neoplasia, genital and dermatological diseases , dysregulation of gut microbiota (dysbiosis) has also been found to be associated with increased risk of allergies. Probiotics are increasingly being employed to correct dysbiosis and, in turn, to modulate allergic diseases. However, several factors like strain variations and effector metabolites or component of them in a bacterial species can affect the efficacy of those as probiotics. On the other hand, host variations like geographical locations, food habits etc. could also affect the expected results from probiotic usage. Thus, there is a glaring deficiency in our approach to establish probiotics as an irrefutable treatment avenue for suitable disorders. In this review, we explicate on the reported probiotics and their effects on certain allergic diseases like atopic dermatitis, food allergy and asthma to establish their utility. We propose possible measures like elucidation of effector molecules and functional mechanisms of probiotics towards establishing probiotics for therapeutic use. Certain probiotics studies have led to very alarming outcomes which could have been precluded, had effective guidelines been in place. Thus, we also propose ways to secure the safety of probiotics. Overall, our efforts tend to propose necessary discovery and quality assurance guidelines for developing probiotics as potential immunomodulatory 'Pharmabiotics.'
ISSN:2092-7355
2092-7363
DOI:10.4168/aair.2018.10.6.575