Bioactive enmein-type 6,7-seco-ent-kaurane diterpenoids: natural products, synthetic derivatives and apoptosis related mechanism

Diterpenoids are important and widely distributed natural compounds with various biological effects, including antitumor, anti-inflammatory and so on. Great efforts have been put in phytochemistry research on diterpenoids. A number of structural modified derivatives and pharmacophore incorporated hy...

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Bibliographic Details
Published in:Archives of pharmacal research 2018, 41(11), , pp.1051-1061
Main Authors: Li, Haonan, Sun, Baojia, Wang, Mingying, Hu, Xu, Gao, Xiang, Xu, Shengtao, Xu, Yongnan, Xu, Jinyi, Hua, Huiming, Li, Dahong
Format: Article
Language:English
Subjects:
Animals
Anti-Infective Agents - chemical synthesis
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
Antineoplastic Agents, Phytogenic - chemical synthesis
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Apoptosis - drug effects
Biological Products - chemical synthesis
Biological Products - chemistry
Biological Products - pharmacology
Cell Line, Tumor
Cell Proliferation - drug effects
Diterpenes - chemical synthesis
Diterpenes - chemistry
Diterpenes - pharmacology
Diterpenes, Kaurane - chemical synthesis
Diterpenes, Kaurane - chemistry
Diterpenes, Kaurane - pharmacology
Drug Design
Humans
Medicine
Microbial Sensitivity Tests
Molecular Structure
Pharmacology/Toxicology
Pharmacy
Review
약학
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Summary:Diterpenoids are important and widely distributed natural compounds with various biological effects, including antitumor, anti-inflammatory and so on. Great efforts have been put in phytochemistry research on diterpenoids. A number of structural modified derivatives and pharmacophore incorporated hybrids were also designed and synthesized with promising therapeutic effects. Among the hopefuls, enmein-type 6,7- seco - ent -kaurane diterpenoids with unique ring system and stereogenic centers exhibit attractive activities. Based on their lead-like properties, enmein-type diterpenoids are suitable for further medicinal study. The derivatives were biologically evaluated and showed promising activities, which warranted in-depth research for further understanding. In this review, the natural bioactive enmein-type diterpenoids and the synthetic derivatives were comprehensively summarized.
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-018-1078-3