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Chemical constituents of the roots of Codonopsis lanceolata
A new phenylpropanoid ( 1 ), a new alkaloid ( 11 ), and a new natural polyacetylene ( 17 ), together with nine phenolic compounds ( 2 – 10 ), five alkaloids ( 12 – 16 ), three polyacetylenes ( 18 – 20 ), three triterpenoidal saponins ( 21 – 23 ), one phenylethanoid glycoside ( 24) , and three hexyl...
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Published in: | Archives of pharmacal research 2018, 41(11), , pp.1082-1091 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | A new phenylpropanoid (
1
), a new alkaloid (
11
), and a new natural polyacetylene (
17
), together with nine phenolic compounds (
2
–
10
), five alkaloids (
12
–
16
), three polyacetylenes (
18
–
20
), three triterpenoidal saponins (
21
–
23
), one phenylethanoid glycoside (
24)
, and three hexyl glycosides (
25
–
27
) with previous known structures, were isolated from the roots of
Codonopsis lanceolata
. All of the isolates
1
–
27
were evaluated for their inhibitory effects on LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages and cell viability in A2780 human ovarian cancer cells. Among the isolates, lancemasides A and B have a significant inhibitory effect on the production of NO in RAW264.7 cells (IC
50
values |
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ISSN: | 0253-6269 1976-3786 |
DOI: | 10.1007/s12272-018-1080-9 |