Characterization of the dynamic change of microRNA expression in mice hypothalamus during the time of female puberty

Puberty onset is a milestone in sexual development. A tumor suppress gene (TSG) network had been reported to be involved in the regulation of female puberty onset. The observations in rodents and primates showed a potential link between microRNAs and puberty onset. To figure out what miRNAs play rol...

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Bibliographic Details
Published in:Genes & genomics 2018, 40(3), , pp.295-304
Main Authors: Omariba, Gideon, Tong, Li, Wang, Maochun, Li, Kai, Zhou, Yuxun, Xiao, Junhua
Format: Article
Language:English
Subjects:
Animal Genetics and Genomics
Bioinformatics
Biomedical and Life Sciences
Cancer
Cerebral cortex
Gene expression
Gonadotropin-releasing hormone
Human Genetics
Hypothalamus
Life Sciences
Microbial Genetics and Genomics
MicroRNAs
miRNA
Plant Genetics and Genomics
Polymerase chain reaction
Puberty
Research Article
Rodents
생물학
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Summary:Puberty onset is a milestone in sexual development. A tumor suppress gene (TSG) network had been reported to be involved in the regulation of female puberty onset. The observations in rodents and primates showed a potential link between microRNAs and puberty onset. To figure out what miRNAs play roles in this important biological process, profilings of microRNAs in the hypothalamus of female mice from three different pubertal stages, juvenile [postnatal day (P10)], early pubertal (P25) and pubertal (P30) were performed on the Affymetrix GeneChip miRNA 3.0 Arrays, the cerebral cortex (CTX) was used as a control tissue. 20 miRNAs were shown to be differentially expressed in hypothalamus (fold change > 1.5, P 
ISSN:1976-9571
2092-9293
DOI:10.1007/s13258-017-0633-5