T-Cell Receptor Rearrangements Determined Using Fragment Analysis in Patients With T-Acute Lymphoblastic Leukemia

Chromosomal abnormalities and common genetic rearrangements related to T-acute lymphoblastic leukemia (T-ALL) are not clear. We investigated T-cell receptor ( ) rearrangement in Korean T-ALL patients by fragment analysis, examining frequency, association between clinicopathologic characteristics and...

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Bibliographic Details
Published in:Annals of laboratory medicine 2019, 39(2), , pp.125-132
Main Authors: Kim, Hyerim, Kim, In Suk, Chang, Chulhun L, Kong, Sun Young, Lim, Young Tak, Kong, Seom Gim, Cho, Eun Hae, Lee, Eun Yup, Shin, Ho Jin, Park, Hyeon Jin, Eom, Hyeon Seok, Lee, Hyewon
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Language:English
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Summary:Chromosomal abnormalities and common genetic rearrangements related to T-acute lymphoblastic leukemia (T-ALL) are not clear. We investigated T-cell receptor ( ) rearrangement in Korean T-ALL patients by fragment analysis, examining frequency, association between clinicopathologic characteristics and clonality, and feasibility for detecting minimal residual disease (MRD). In 51 Korean patients diagnosed as having T-ALL, rearrangement was analyzed using the IdentiClone gene clonality assay (InVivoScribe Technologies, San Diego, CA, USA) from archived bone marrow specimens. Limit of detection (LOD) and clonal stability at relapse were evaluated. The association between clinical prognosis and clonality was examind by age and immunophenotypic classification. Thirty-eight patients (74.5%) had 62 clonal products of , , and/or rearrangements at diagnosis. Children with T-ALL (
ISSN:2234-3806
2234-3814
DOI:10.3343/alm.2019.39.2.125