Anti-LGI1 Limbic Encephalitis Presented with Atypical Manifestations

Anti-leucine-rich glioma inactivated-1 (LGI1) limbic encephalitis (LE) is a rare neurological disorder that has a subacute course of progressive encephalopathy and fasciobrachial dystonic seizures. We report a patient with anti-LGI1 LE that presented with atypical manifestations that complicated the...

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Bibliographic Details
Published in:Experimental neurobiology 2013, 22(4), , pp.337-340
Main Authors: Lee, Jung-Ju, Lee, Soon-Tae, Jung, Keun-Hwa, Chu, Kon, Lee, Sang Kun
Format: Article
Language:English
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Case Report
뇌과학
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Summary:Anti-leucine-rich glioma inactivated-1 (LGI1) limbic encephalitis (LE) is a rare neurological disorder that has a subacute course of progressive encephalopathy and fasciobrachial dystonic seizures. We report a patient with anti-LGI1 LE that presented with atypical manifestations that complicated the diagnosis. A 62-year-old woman presented with a chronic course of memory disturbance and a subsequent relapse with an altered mental status after 10 months. The patient reported frequent chest pain of squeezing and dull nature, typically lasting 10-30 seconds. The chest pain was related to partial seizures, which were confirmed by video-EEG monitoring. Anti-LGI1 antibody was identified in serum and CSF. The patient's symptoms improved by immune modulation treatment. Patients with anti-LGI1 LE can experience atypical partial seizures, and a chronic relapsing course. Clinical suspicions and video-EEG monitoring are helpful for the early diagnosis and effective immune modulation.
ISSN:1226-2560
2093-8144
DOI:10.5607/en.2013.22.4.337