Inhibitory effect of vitamin C on intrinsic aging in human dermal fibroblasts and hairless mice

Vitamin C significantly reduced senescence-associated β-galactosidase (SA-β-gal) activity, with both the suppression of cell-cycle inhibitors (p53, p21, p16, and pRb) and stimulation of cell-cycle activators (E2F1 and E2F2). Vitamin C also effectively attenuated the hyperactivation of the phosphatid...

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Bibliographic Details
Published in:Food science and biotechnology 2018, 27(2), , pp.555-564
Main Authors: Jeong, Jae-Hong, Kim, Mi-Bo, Kim, Changhee, Hwang, Jae-Kwan
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
Aging
Aging (natural)
AKT protein
Ascorbic acid
Atrophy
beta-galactosidase
cell cycle
cell senescence
Chemistry
Chemistry and Materials Science
Collagen
Cosmetics industry
Elasticity
Fibroblasts
Food Science
Forkhead protein
FOXO3 protein
Galactosidase
Hairless
humans
Kinases
longevity
Mice
Nutrition
Oral administration
p53 Protein
phosphatidylinositol 3-kinase
Protein kinase
Rapamycin
Senescence
Signal transduction
Signaling
SIRT1 protein
Skin
TOR protein
Vitamin C
Water loss
식품과학
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Summary:Vitamin C significantly reduced senescence-associated β-galactosidase (SA-β-gal) activity, with both the suppression of cell-cycle inhibitors (p53, p21, p16, and pRb) and stimulation of cell-cycle activators (E2F1 and E2F2). Vitamin C also effectively attenuated the hyperactivation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase-B (AKT) signaling pathway. The expression of the longevity marker, the mammalian target of rapamycin (mTOR), was down-regulated by vitamin C while the expressions of forkhead box O3a (FoxO3a) and sirtuin1 (SIRT1) were up-regulated by vitamin C. In the middle-aged (MA) mice, oral administration of vitamin C significantly inhibited wrinkle formation, skin atrophy, and loss of elasticity through increasing collagen and elastic fiber. The increase in transepidermal water loss and the decrease in skin hydration were recovered by vitamin C treatment in the MA mice. Overall, vitamin C effectively prevents cellular senescence in vitro and in vivo suggesting it has protective potential against natural aging of the skin.
ISSN:1226-7708
2092-6456
DOI:10.1007/s10068-017-0252-6