Emerging signals modulating potential of ginseng and its active compounds focusing on neurodegenerative diseases

Common features of neurodegenerative diseases (NDDs) include progressive dysfunctions and neuronal injuries leading to deterioration in normal brain functions. At present, ginseng is one of the most frequently used natural products. Its use has a long history as a cure for various diseases because i...

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Bibliographic Details
Published in:Journal of ginseng research 2019, 43(2), , pp.163-171
Main Authors: Jakaria, Md, Kim, Joonsoo, Karthivashan, Govindarajan, Park, Shin-Young, Ganesan, Palanivel, Choi, Dong-Kug
Format: Article
Language:English
Subjects:
Active compounds
Ginseng
Ion channels
Neurodegenerative diseases
Review
Signaling pathway
기타의약학
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Summary:Common features of neurodegenerative diseases (NDDs) include progressive dysfunctions and neuronal injuries leading to deterioration in normal brain functions. At present, ginseng is one of the most frequently used natural products. Its use has a long history as a cure for various diseases because its extracts and active compounds exhibit several pharmacological properties against several disorders. However, the pathophysiology of NDDs is not fully clear, but researchers have found that various ion channels and specific signaling pathways might have contributed to the disease pathogenesis. Apart from the different pharmacological potentials, ginseng and its active compounds modulate various ion channels and specific molecular signaling pathways related to the nervous system. Here, we discuss the signal modulating potential of ginseng and its active compounds mainly focusing on those relevant to NDDs.
ISSN:1226-8453
2093-4947
DOI:10.1016/j.jgr.2018.01.001