Effect of vitamin E in nonalcoholic fatty liver disease with metabolic syndrome: A propensity score-matched cohort study

• Published in: Clinical and molecular hepatology 2015, 21(4), , pp.379-386
• Main Authors: Kim, Gi Hyun, Chung, Jung Wha, Lee, Jong Ho, Ok, Kyeong Sam, Jang, Eun Sun, Kim, Jaihwan, Shin, Cheol Min, Park, Young Soo, Hwang, Jin-Hyeok, Jeong, Sook-Hyang, Kim, Nayoung, Lee, Dong Ho, Kim, Jin-Wook
• Format: Article
• Language: English
• Subjects: Adult; Aged; Alanine Transaminase - blood; Alcohol; Aspartate Aminotransferases - blood; Blood platelets; Blood pressure; Body mass index; Body Weight; Cholesterol; Cohort analysis; Cohort Studies; Diabetes; Female; Glucose; Hepatitis; Hospitals; Humans; Insulin resistance; Lipoproteins, HDL - blood; Lipoproteins, LDL - blood; Liver - pathology; Liver diseases; Male; Metabolic disorders; Metabolic syndrome; Metabolic Syndrome - complications; Metabolic Syndrome - diagnosis; Metabolic Syndrome - drug therapy; Middle Aged; Non-alcoholic Fatty Liver Disease - complications; Non-alcoholic Fatty Liver Disease - diagnosis; Non-alcoholic Fatty Liver Disease - drug therapy; Nonalcoholic fatty liver disease; Original; Outpatient care facilities; Propensity Score; Republic of Korea; Retrospective Studies; Vitamin E; Vitamin E - therapeutic use; Womens health; 내과학
• ISSN: 2287-2728; 2287-285X
• DOI: 10.3350/cmh.2015.21.4.379

Vitamin E improves the biochemical profiles and liver histology in nonalcoholic steatohepatitis, but the role of vitamin E is not clearly defined in the management of nonalcoholic fatty liver disease (NAFLD) which includes both simple steatosis and steatohepatitis. Co-morbid metabolic syndrome increases the probability of steatohepatitis in NAFLD. In this study, we aimed to determine the short-term effects of vitamin E and off-treatment durability of response in a propensity-score matched cohort of NAFLD patients with metabolic syndrome. A retrospective cohort was constructed by retrieving 526 consecutive NAFLD patients from the electronic medical record data warehouse of a tertiary referral hospital in South Korea. Among them, 335 patients (63.7%) had metabolic syndrome and were eligible for vitamin E therapy. In order to assess the effect of vitamin E, propensity score matching was used by matching covariates between control patients (n=250) and patients who received vitamin E (n=85). The PS-matched vitamin E group (n=58) and control group (n=58) exhibited similar baseline metabolic profiles. After 6 months of vitamin E therapy, the mean ALT levels decreased significantly compared to PS-matched control (P