Prognostic Implications of MicroRNA-21 Overexpression in Invasive Ductal Carcinomas of the Breast

Among more than 500 microRNAs, microRNA-21 (miR-21) is known to act as an oncogene. The aim of this study was to investigate the significance of miR-21 expression level in relation with clinicopathological factors and prognosis in breast cancer. MicroRNA was extracted from cancer and normal breast t...

Full description

Saved in:
Bibliographic Details
Published in:Journal of breast cancer 2011, 14(4), 57, pp.269-275
Main Authors: Lee, Jung Ah, Lee, Hye Yoon, Lee, Eun Sook, Kim, Insun, Bae, Jeoung Won
Format: Article
Language:English
Subjects:
Original
일반외과학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Among more than 500 microRNAs, microRNA-21 (miR-21) is known to act as an oncogene. The aim of this study was to investigate the significance of miR-21 expression level in relation with clinicopathological factors and prognosis in breast cancer. MicroRNA was extracted from cancer and normal breast tissue of 109 breast cancer patients who underwent surgery from 2002 to 2004 using the Taqman® MicroRNA Assay. The correlation between miR-21 expression and clinicopathologic features was analyzed and the significance of miR-21 as a prognostic factor and its relationship with survival was determined. MiR-21 expression was higher in cancer tissues than in normal tissues (p
ISSN:1738-6756
2092-9900
DOI:10.4048/jbc.2011.14.4.269