Patterns of recurrence after breast-conserving treatment for early stage breast cancer by molecular subtype

To study clinical features and patterns of recurrence after breast-conserving treatment (BCT) for three molecular subtypes of early stage breast cancer. The sample studied included 596 patients with T1-2N0-1 breast cancer who received BCT. Three groups were defined by receptor status. Luminal: estro...

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Bibliographic Details
Published in:Journal of breast cancer 2011, 14(1), 52, pp.46-51
Main Authors: Noh, Jae Myoung, Choi, Doo Ho, Huh, Seung Jae, Park, Won, Yang, Jung Hyun, Nam, Seok Jin, Im, Young Hyuck, Ahn, Jin Seok
Format: Article
Language:English
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일반외과학
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Summary:To study clinical features and patterns of recurrence after breast-conserving treatment (BCT) for three molecular subtypes of early stage breast cancer. The sample studied included 596 patients with T1-2N0-1 breast cancer who received BCT. Three groups were defined by receptor status. Luminal: estrogen receptor (ER) or progesterone receptor (PR) positive; triple negative (TN): ER, PR, and epidermal growth factor receptor-2 (HER2) receptor negative; and HER2 overexpressing: ER and PR negative but HER2 receptor positive. The number of patients in each group was 408 (68.5%), 105 (17.6%), and 83 (13.9%), respectively. The median follow-up period was 79 months. The TN and HER2 subtypes occurred in younger patients (p=0.0007) and had higher nuclear grade and poorer histologic grade (p
ISSN:1738-6756
2092-9900
DOI:10.4048/jbc.2011.14.1.46