꽈배기모자반 추출물이 3T3-L1 지방세포 분화에 미치는 영향

In this study, the potential capacity of the crude extract and its solvent fractions from S. siliquanstrum against adipocyte differentiation were evaluated in 3T3-L1 adipocytes. The anti-adipogenic effect of S. siliquanstrum was evidenced by the fact that its crude extract decreases the lipid accumu...

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Bibliographic Details
Published in:Ocean and polar research 2015, 37(4), , pp.279-285
Main Authors: 공창숙, 이정임, 권명숙, 서영완, Kong, Chang-Suk, Lee, Jung Im, Kwon, Myeong Sook, Seo, Youngwan
Format: Article
Language:Korean
Subjects:
해양학
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Summary:In this study, the potential capacity of the crude extract and its solvent fractions from S. siliquanstrum against adipocyte differentiation were evaluated in 3T3-L1 adipocytes. The anti-adipogenic effect of S. siliquanstrum was evidenced by the fact that its crude extract decreases the lipid accumulation of differentiating cells and the expression levels of crucial adipogenesis markers, peroxisome proliferator-activated receptor $(PPAR){\gamma}$ and CCAAT/enhancer-binding protein $(C/EBP){\alpha}$. All solvent fractions except the water fraction showed an observable decrease in lipid accumulation and $PPAR{\gamma}$ and $C/EBP{\alpha}$ expressions. In conclusion, these results suggest that S. siliquanstrum possesses obesity inhibiting components, which may possibly be used as a valuable anti-obesity agent for reducing the risk of obesity.
ISSN:1598-141X
2234-7313
DOI:10.4217/OPR.2015.37.4.279