P-Protein: A Novel Target for Skin-whitening Agent

Skin pigmentation is the most visible phenotype character of human beings and is regulated by many factors. Despite recent advances, the whole process of melanogenesis is not well understood. More than 400 genes are involved in human pigmentation and one of them is the pink-eyed dilution gene (p-gen...

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Bibliographic Details
Published in:Biotechnology and bioprocess engineering 2019, 24(1), , pp.76-84
Main Authors: Singh, Birendra Kumar, Kim, Eun-Ki
Format: Article
Language:English
Subjects:
Albinism
Biotechnology
Chemistry
Chemistry and Materials Science
Cosmetics
Dilution
Genes
Genotype & phenotype
Hair
Industrial and Production Engineering
Melanin
Minority & ethnic groups
Mutation
Patients
Phenotypes
Pigmentation
Point mutation
Proteins
Reaction mechanisms
Review Paper
Skin
Skin pigmentation
Strabismus
White people
생물공학
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Summary:Skin pigmentation is the most visible phenotype character of human beings and is regulated by many factors. Despite recent advances, the whole process of melanogenesis is not well understood. More than 400 genes are involved in human pigmentation and one of them is the pink-eyed dilution gene (p-gene). The p-gene mutation causes oculocutaneous albinism-2 (OCA-2) in humans. OCA type 2 has a highly variable phenotype. The reaction mechanism of the p-gene is still a mystery. In this review, we focused on the role of the p-gene in the process of melanogenesis. Melanogenesis occurs in a specialized cellular organelle termed as melanosome in which the skin pigment (melanin) is produced. This review is to provide the function of p-gene, their product (p-protein) and their potentials in developing new generation cosmetics.
ISSN:1226-8372
1976-3816
DOI:10.1007/s12257-018-0241-5