The protective effects of Gastrodia elata Blume extracts on middle cerebral artery occlusion in rats

To investigate the effects of Gastrodia elata Blume (GEB) and 4-hydroxybenzyl alcohol (HBA) on brain damage, GEB or HBA was administered orally for 14 days before middle cerebral artery occlusion (MCAO). After 24 h reperfusion, the proportion of circling was significantly reduced in the GEB (79%) or...

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Bibliographic Details
Published in:Food science and biotechnology 2019, 28(3), , pp.857-864
Main Authors: Seok, Pu Reum, Oh, Su Jin, Choi, Jin Woo, Lim, Cho Rong, Choi, Jong Ryeol, Kim, Jung Hoan, Shin, Jae-Ho
Format: Article
Language:English
Subjects:
Adhesion tests
Alcohols
Apoptosis
biotechnology
Brain
Brain damage
Brain injury
Cerebral blood flow
Chemistry
Chemistry and Materials Science
cortex
Damage prevention
Food Science
Gastrodia elata
hippocampus
infarction
Inflammation
Ischemia
nerve tissue
Nutrition
Occlusion
Reperfusion
Tumor necrosis factor-α
식품과학
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Summary:To investigate the effects of Gastrodia elata Blume (GEB) and 4-hydroxybenzyl alcohol (HBA) on brain damage, GEB or HBA was administered orally for 14 days before middle cerebral artery occlusion (MCAO). After 24 h reperfusion, the proportion of circling was significantly reduced in the GEB (79%) or HBA (69%) group compared to the MCAO group (100%) in the corner test, and the removal time in the adhesive removal test was significantly decreased in the GEB (117 ± 21.0 s) and HBA (101 ± 20.9 s) groups compared to the MCAO group (161 ± 12.6 s). GEB treatment significantly reduced infarct volume compared to the MCAO group. In the GEB and HBA group, necrosis of nerve cells in hippocampus and cortex, expressions of TNF-α and TUNEL positive cells were significantly reduced compared to the MCAO group. These results suggest that GEB and HBA prevents brain damage by anti-inflammatory and anti-apoptotic effects.
ISSN:1226-7708
2092-6456
DOI:10.1007/s10068-018-0516-9