Pulmonary Protective Functions of Rare Ginsenoside Rg4 on Particulate Matter-induced Inflammatory Responses

Inhalation of fine particulate matter (PM 2.5 ) is associated with an increase in lung injury caused by the loss of integrity of the vascular barrier. The rare ginsenoside Rg4 is a main protopanaxatriol type ginsenoside of black ginseng (BG). The aim of this study was to investigate the beneficial e...

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Bibliographic Details
Published in:Biotechnology and bioprocess engineering 2019, 24(3), , pp.445-453
Main Authors: Lee, Wonhwa, Ku, Sae-Kwang, Kim, Ji-Eun, Choi, Ga-Eun, Song, Gyu-Yong, Bae, Jong-Sup
Format: Article
Language:English
Subjects:
AKT protein
Alveoli
Animal tissues
Biotechnology
Bronchus
Cell activation
Chemistry
Chemistry and Materials Science
Disruption
Endothelial cells
Ginseng
Ginsenosides
Histology
Industrial and Production Engineering
Infiltration
Inflammation
Inhalation
Integrity
Kinases
Leukocyte migration
Leukocytes
Lungs
MAP kinase
Particulate emissions
Particulate matter
Permeability
Protein kinase
Proteins
Reactive oxygen species
Research Paper
Respiration
생물공학
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Summary:Inhalation of fine particulate matter (PM 2.5 ) is associated with an increase in lung injury caused by the loss of integrity of the vascular barrier. The rare ginsenoside Rg4 is a main protopanaxatriol type ginsenoside of black ginseng (BG). The aim of this study was to investigate the beneficial effects of Rg4 on PM-induced lung endothelial cell (EC) barrier disruption and pulmonary inflammation. Permeability, leukocyte migration, activation of proinflammatory proteins, generation of reactive oxygen species (ROS), and histology were examined in PM 2.5 -treated EC and mice. Rg4 significantly scavenged PM 2.5 -induced ROS, inhibited ROS-induced activation of p38 mitogen-activated protein kinase (MAPK), activated Akt in purified pulmonary endothelial cells, which helped maintain endothelial integrity. Further, Rg4 reduced vascular protein leakage, leukocyte infiltration, and proinflammatory cytokine release in bronchoalveolar lavage fluids in PM-induced mouse lung tissues. Data suggested that Rg4 might exhibit protective effects in PM-induced inflammatory lung injury and vascular hyperpermeability.
ISSN:1226-8372
1976-3816
DOI:10.1007/s12257-019-0096-4