Role of innate immunity in the pathogenesis of type 1 and type 2 diabetes

The importance of innate immunity in host defense is becoming clear after discovery of innate immune receptors such as Toll-like receptor or Nod-like receptor. Innate immune system plays an important role in diverse pathological situations such as autoimmune diseases. Role of innate immunity in the...

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Bibliographic Details
Published in:Journal of Korean medical science 2014, 29(8), 191, pp.1038-1041
Main Author: Lee, Myung-Shik
Format: Article
Language:English
Subjects:
Animals
Cytokines - immunology
Diabetes Mellitus, Type 1 - immunology
Diabetes Mellitus, Type 2 - immunology
Humans
Immunity, Innate - immunology
Inflammasomes - immunology
Models, Immunological
Pancreas - immunology
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Summary:The importance of innate immunity in host defense is becoming clear after discovery of innate immune receptors such as Toll-like receptor or Nod-like receptor. Innate immune system plays an important role in diverse pathological situations such as autoimmune diseases. Role of innate immunity in the pathogenesis of metabolic disorders such as type 2 diabetes, metabolic syndrome or atherosclerosis that has not been previously considered as inflammatory disorders, is also being appreciated. Here, the role of innate immunity in the development of type 1 diabetes, a classical organ-specific autoimmune disease, and type 2 diabetes will be discussed, focusing on the role of specific innate immune receptors involved in these disease processes.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2014.29.8.1038