The First Successful Heart-Lung Transplant in a Korean Child with Humidifier Disinfectant-Associated Interstitial Lung Disease

From 2006 to 2011, an outbreak of a particular type of childhood interstitial lung disease occurred in Korea. The condition was intractable and progressed to severe respiratory failure, with a high mortality rate. Moreover, in several familial cases, the disease affected young women and children sim...

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Bibliographic Details
Published in:Journal of Korean medical science 2016, 31(5), 215, pp.817-821
Main Authors: Jhang, Won Kyoung, Park, Seong Jong, Lee, Eun, Yang, Song I, Hong, Soo Jong, Seo, Ju-Hee, Kim, Hyung-Young, Park, Jeong-Jun, Yun, Tae-Jin, Kim, Hyeong Ryul, Kim, Yong-Hee, Kim, Dong Kwan, Park, Seung-Il, Lee, Sang-Oh, Hong, Sang-Bum, Shim, Tae-Sun, Choi, In-Cheol, Yu, Jinho
Format: Article
Language:English
Subjects:
Case Report
Child, Preschool
Disinfectants - toxicity
Extracorporeal Membrane Oxygenation
Female
Humans
Humidifiers
Lung - drug effects
Lung - pathology
Lung Diseases, Interstitial - chemically induced
Lung Diseases, Interstitial - pathology
Lung Diseases, Interstitial - therapy
Lung Transplantation
Republic of Korea
Respiratory Rate
Retrospective Studies
Thorax - diagnostic imaging
Tomography, X-Ray Computed
의학일반
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Summary:From 2006 to 2011, an outbreak of a particular type of childhood interstitial lung disease occurred in Korea. The condition was intractable and progressed to severe respiratory failure, with a high mortality rate. Moreover, in several familial cases, the disease affected young women and children simultaneously. Epidemiologic, animal, and post-interventional studies identified the cause as inhalation of humidifier disinfectants. Here, we report a 4-year-old girl who suffered from severe progressive respiratory failure. She could survive by 100 days of extracorporeal membrane oxygenation support and finally, underwent heart-lung transplantation. This is the first successful pediatric heart-lung transplantation carried out in Korea.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2016.31.5.817