Anaphylaxis to Polyethylene Glycol (Colyte®) in a Patient with Diverticulitis

Polyethylene glycols (PEGs) are believed to be chemically inert agents, but larger PEG polymers could have immunogenicity. A 39-year-old man was referred to emergency room for loss of consciousness and dyspnea after taking of PEG-3350 (Colyte®). In laboratory findings, the initial serum tryptase lev...

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Bibliographic Details
Published in:Journal of Korean medical science 2016, 31(10), 220, pp.1662-1663
Main Authors: Lee, So Hee, Hwang, Sun Hyuk, Park, Jin Soo, Park, Hae Sim, Shin, Yoo Seob
Format: Article
Language:English
Subjects:
Adult
Anaphylaxis - chemically induced
Anaphylaxis - diagnosis
Case Report
Diverticulitis - complications
Diverticulitis - diagnosis
Electrolytes - adverse effects
Humans
Male
Polyethylene Glycols - adverse effects
Risk Factors
Skin Tests
Tryptases - blood
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Summary:Polyethylene glycols (PEGs) are believed to be chemically inert agents, but larger PEG polymers could have immunogenicity. A 39-year-old man was referred to emergency room for loss of consciousness and dyspnea after taking of PEG-3350 (Colyte®). In laboratory findings, the initial serum tryptase level was increased to 91.9 mg/L (normal range: 0.00-11.40 mg/L) without any other laboratory abnormalities. The intradermal test with 10 mg/mL Colyte® showed a 5 × 5 mm wheal, but basophil activation and histamine releasability tests were negative. PEG-3350 is widely used as an osmotic laxative due to its lack of absorption from the gastrointestinal tract. However, the loss of mucosal integrity at gastrointestinal membrane such as diverticulitis may be a predisposing factor for anaphylaxis to Colyte®. We report a case of anaphylaxis induced by the ingestion of PEG-3350 in a patient with diverticulitis which might be a risk factor of anaphylaxis.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2016.31.10.1662