Change in somatostatinergic tone of acromegalic patients according to the size of growth hormone-producing pituitary tumors

The aim of this study was to investigate the relationship between somatostatinergic tone (SST) and the size of growth hormone (GH)-producing pituitary tumors. GH levels of 29 patients with newly diagnosed acromegaly were measured using a 75-gram oral glucose tolerance test (OGTT), an insulin toleran...

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Published in:Journal of Korean medical science 2013, 28(12), 183, pp.1774-1780
Main Authors: Chin, Sang Ouk, Chon, Suk, Hwang, You-Cheol, Jeong, In-Kyung, Oh, Seungjoon, Kim, Sung-Woon
Format: Article
Language:English
Subjects:
Acromegaly - diagnosis
Acromegaly - pathology
Adenoma - drug therapy
Adenoma - pathology
Adult
Aged
Antineoplastic Agents, Hormonal - therapeutic use
Female
Glucose Tolerance Test
Human Growth Hormone - blood
Human Growth Hormone - secretion
Humans
Insulin - blood
Insulin-Like Growth Factor I - analysis
Male
Middle Aged
Octreotide - therapeutic use
Original
Pituitary Neoplasms - drug therapy
Pituitary Neoplasms - pathology
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Summary:The aim of this study was to investigate the relationship between somatostatinergic tone (SST) and the size of growth hormone (GH)-producing pituitary tumors. GH levels of 29 patients with newly diagnosed acromegaly were measured using a 75-gram oral glucose tolerance test (OGTT), an insulin tolerance test (ITT), and an octreotide suppression test (OST). Differences between GH levels during the ITT and the OGTT (ΔGHIO), and between the OGTT and the OST at the same time point (ΔGHOS) were compared according to the size of the tumor and the response pattern to the OST. ΔGHIO of macroadenomas (n=22) was non-significantly higher than those of microadenomas while ΔGHOS of macroadenomas were significantly higher than those of microadenomas. According to further analyses of macroadenomas based on the response pattern to the OST, GH levels during the ITT were significantly higher in non-responders. ΔGHOS showed near-significant differences between responders and non-responders. In conclusion, as the size of the pituitary tumor increases, the effect of glucose on SST appears to be attenuated. Macroadenomas that are non-responders to the OST possess a portion of GH secretion exceeding the range of regulation by SST.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2013.28.12.1774