Comparison of specific IgE antibodies to wheat component allergens in two phenotypes of wheat allergy

Specific IgE to gliadin was proposed as a marker for wheat dependent exercise induced anaphylaxis, while Tri a 14 was found to induce IgE response in baker's asthma. We evaluated whether these components could be used for discriminating phenotypes of wheat allergy. Twenty-nine patients who were...

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Bibliographic Details
Published in:Journal of Korean medical science 2013, 28(11), 182, pp.1697-1699
Main Authors: Nam, Young-Hee, Hwang, Eui-Kyung, Jin, Hyun Jung, Lee, Jeong Min, Shin, Yoo-Seob, Ye, Young-Min, Palacin, Arantxa, Salcedo, Gabriel, Lee, Soo-Young, Park, Hae-Sim
Format: Article
Language:English
Subjects:
Adult
Anaphylaxis - immunology
Antigens, Plant - immunology
Asthma - blood
Asthma - diagnosis
Asthma - immunology
Biomarkers - blood
Brief Communication
Carrier Proteins - immunology
Female
Gliadin - immunology
Humans
Immunoglobulin E - blood
Immunoglobulin E - immunology
Male
Phenotype
Triticum - immunology
Urticaria - immunology
Wheat Hypersensitivity - diagnosis
Wheat Hypersensitivity - immunology
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Summary:Specific IgE to gliadin was proposed as a marker for wheat dependent exercise induced anaphylaxis, while Tri a 14 was found to induce IgE response in baker's asthma. We evaluated whether these components could be used for discriminating phenotypes of wheat allergy. Twenty-nine patients who were wheat-induced anaphylaxis and/or urticaria (n=21, group I) and baker's asthma (n=8, group II) were enrolled. The prevalence of serum specific IgE to Tri a 14 was higher in group II (25%) than in group I (4.8%), while the serum specific IgE to gliadin was significantly higher in group I (70%) than in group II (12.5%). The cutoff value for predicting the baker's asthma using the ratio of serum specific IgE to Tri a 14 to gliadin was 742.8 optical density×1,000/(kU/L) with high sensitivity and specificity. These findings suggest that Tri a 14/gliadin may be a potential marker for predicting baker's asthma.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2013.28.11.1697