Hypoxemia and arrhythmia during daily activities and six-minute walk test in fibrotic interstitial lung diseases

We performed 24-hr monitoring of pulse oximetric saturation (SpO(2)) with ECG and six-minute walk test (6MWT) in 19 patients with fibrotic interstitial lung diseases (ILD) to investigate; 1) The frequency and severity of hypoxemia and dysrhythmia during daily activities and 6MWT, 2) safety of 6MWT,...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Korean medical science 2011, 26(3), 149, pp.372-378
Main Authors: Park, Jeong Hyun, Jegal, Yangjin, Shim, Tae Sun, Lim, Chae-Man, Lee, Sang Do, Koh, Younsuck, Kim, Woo Sung, Kim, Won Dong, du Bois, Roland, Do, Kyung-Hyun, Kim, Dong Soon
Format: Article
Language:English
Subjects:
Activities of Daily Living
Aged
Arrhythmias, Cardiac - physiopathology
Dyspnea - physiopathology
Electrocardiography, Ambulatory
Exercise Test
Exercise Tolerance
Female
Humans
Hypoxia - physiopathology
Lung Diseases, Interstitial - physiopathology
Male
Middle Aged
Motor Activity - physiology
Original
Oximetry
Respiratory Function Tests
Sleep
Walking
의학일반
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We performed 24-hr monitoring of pulse oximetric saturation (SpO(2)) with ECG and six-minute walk test (6MWT) in 19 patients with fibrotic interstitial lung diseases (ILD) to investigate; 1) The frequency and severity of hypoxemia and dysrhythmia during daily activities and 6MWT, 2) safety of 6MWT, and 3) the parameters of 6MWT which can replace 24-hr continuous monitoring of SpO(2) to predict hypoxemia during daily activities. All patients experienced waking hour hypoxemia, and eight of nineteen patients spent > 10% of waking hours in hypoxemic state. Most patients experienced frequent arrhythmia, mostly atrial premature contractions (APCs) and ventricular premature contractions (VPCs). There were significant correlation between the variables of 6MWT and hypoxemia during daily activities. All of the patients who desaturated below 80% before 300 meters spent more than 10% of waking hour in hypoxemia (P = 0.018). In contrast to waking hour hypoxemia, SpO(2) did not drop significantly during sleep except in the patients whose daytime resting SpO(2) was already low. In conclusion, patients with fibrotic ILD showed significant period of hypoxemia during daily activities and frequent VPCs and APCs. Six-minute walk test is a useful surrogate marker of waking hour hypoxemia and seems to be safe without continuous monitoring of SpO(2).
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2011.26.3.372