Incidence and risk factors of steroid-induced diabetes in patients with respiratory disease

Glucocorticoids are effective for treating several respiratory diseases. However, they can cause hyperglycemia. This study determined the incidence and risk factors of steroid-induced diabetes mellitus (S-DM) in patients treated with glucocorticoid for respiratory diseases. A retrospective study exa...

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Bibliographic Details
Published in:Journal of Korean medical science 2011, 26(2), 148, pp.264-267
Main Authors: Kim, Seo Yun, Yoo, Chul-Gyu, Lee, Chun Taeg, Chung, Hee Soon, Kim, Young Whan, Han, Sung Koo, Shim, Young-Soo, Yim, Jae-Joon
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Blood Glucose - metabolism
Diabetes Mellitus - chemically induced
Diabetes Mellitus - epidemiology
Female
Glucocorticoids - adverse effects
Glucocorticoids - therapeutic use
Humans
Logistic Models
Lung Diseases - complications
Lung Diseases - drug therapy
Male
Middle Aged
Original
Retrospective Studies
Risk Factors
Young Adult
의학일반
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Summary:Glucocorticoids are effective for treating several respiratory diseases. However, they can cause hyperglycemia. This study determined the incidence and risk factors of steroid-induced diabetes mellitus (S-DM) in patients treated with glucocorticoid for respiratory diseases. A retrospective study examined patients with respiratory diseases treated with a prednisolone-equivalent glucocorticoid dose exceeding 20 mg/day for at least 4 weeks between January 2003 and December 2008. Patients whose initial random glucose level exceeded 200 mg/dL or who had pre-existing diabetes were excluded. S-DM was defined as a fasting glucose concentration exceeding 126 mg/dL or a random glucose concentration exceeding 200 mg/dL at least twice after beginning steroid treatment. A total of 231 patients with respiratory diseases met the inclusion criteria. Their median age was 55 yr, and 139 were female. The median cumulative prednisolone-equivalent glucocorticoid dose was 4,965 mg, and the median duration of steroid treatment was 193 days. S-DM was diagnosed in 34 (14.7%) of 231 patients. Multivariate logistic regression identified older age (odds ratio 1.05, 95% confidence interval 1.02-1.09) as a risk factor for S-DM. S-DM is frequent among patients with respiratory diseases treated with glucocorticoid. Clinicians should be aware of the possibility of S-DM, especially among elderly patients.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2011.26.2.264