Functional and histologic changes after repeated transcranial direct current stimulation in rat stroke model

Transcranial direct current stimulation (tDCS) is associated with enhancement or weakening of the NMDA receptor activity and change of the cortical blood flow. Therefore, repeated tDCS of the brain with cerebrovascular injury will induce the functional and histologic changes. Sixty-one Sprague-Dawle...

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Bibliographic Details
Published in:Journal of Korean medical science 2010, 25(10), 143, pp.1499-1505
Main Authors: Kim, Sang Jun, Kim, Byeong Kwon, Ko, Young Jin, Bang, Moon Suk, Kim, Man Ho, Han, Tai Ryoon
Format: Article
Language:English
Subjects:
Animals
Axons - pathology
Cerebral Cortex - physiology
Disease Models, Animal
Electric Stimulation
Motor Activity - physiology
Original
Rats
Rats, Sprague-Dawley
Stroke - metabolism
Stroke - pathology
Stroke - physiopathology
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Summary:Transcranial direct current stimulation (tDCS) is associated with enhancement or weakening of the NMDA receptor activity and change of the cortical blood flow. Therefore, repeated tDCS of the brain with cerebrovascular injury will induce the functional and histologic changes. Sixty-one Sprague-Dawley rats with cerebrovascular injury were used. Twenty rats died during the experimental course. The 41 rats that survived were allocated to the exercise group, the anodal stimulation group, the cathodal stimulation group, or the control group according to the initial motor function. Two-week treatment schedules started from 2 days postoperatively. Garcia, modified foot fault, and rota-rod performance scores were checked at 2, 9, and 16 days postoperatively. After the experiments, rats were sacrificed for the evaluation of histologic changes (changes of the white matter axon and infarct volume). The anodal stimulation and exercise groups showed improvement of Garcia's and modified foot fault scores at 16 days postoperatively. No significant change of the infarct volume happened after exercise and tDCS. Neuronal axons at the internal capsule of infarct hemispheres showed better preserved axons in the anodal stimulation group. From these results, repeated tDCS might have a neuroprotective effect on neuronal axons in rat stroke model.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2010.25.10.1499