Usefulness of non-invasive markers for predicting significant fibrosis in patients with chronic liver disease

The purpose of this prospective study was to verify and compare the strengths of various blood markers and fibrosis models in predicting significant liver fibrosis. One hundred fifty-eight patients with chronic liver disease who underwent liver biopsy were enrolled. The mean age was 41 yr and male p...

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Bibliographic Details
Published in:Journal of Korean medical science 2010, 25(1), 134, pp.67-74
Main Authors: Lee, Han Hyo, Seo, Yeon Seok, Um, Soon Ho, Won, Nam Hee, Yoo, Hanna, Jung, Eun Suk, Kwon, Yong Dae, Park, Sanghoon, Keum, Bora, Kim, Yong Sik, Yim, Hyung Joon, Jeen, Yoon Tae, Chun, Hoon Jai, Kim, Chang Duck, Ryu, Ho Sang
Format: Article
Language:English
Subjects:
Adult
alpha-Macroglobulins - analysis
Biomarkers - blood
Chronic Disease
Fatty Liver - complications
Female
Fibrosis
Haptoglobins - analysis
Hepatitis B - complications
Hepatitis C - complications
Humans
Hyaluronic Acid - blood
Liver Cirrhosis - complications
Liver Cirrhosis - diagnosis
Liver Diseases - complications
Liver Diseases - diagnosis
Male
Middle Aged
Original
Predictive Value of Tests
Prospective Studies
ROC Curve
의학일반
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Summary:The purpose of this prospective study was to verify and compare the strengths of various blood markers and fibrosis models in predicting significant liver fibrosis. One hundred fifty-eight patients with chronic liver disease who underwent liver biopsy were enrolled. The mean age was 41 yr and male patients accounted for 70.2%. The common causes of liver disease were hepatitis B (67.7%) and C (16.5%) and fatty liver (9.5%). Stages of liver fibrosis (F0-4) were assessed according to the Batts and Ludwig scoring system. Significant fibrosis was defined as > or =F2. Sixteen blood markers were measured along with liver biopsy, and estimates of hepatic fibrosis were calculated using various predictive models. Predictive accuracy was evaluated with a receiver-operating characteristics (ROC) curve. Liver biopsy revealed significant fibrosis in 106 cases (67.1%). On multivariate analysis, alpha2-macroglobulin, hyaluronic acid, and haptoglobin were found to be independently related to significant hepatic fibrosis. A new predictive model was constructed based on these variables, and its area under the ROC curve was 0.91 (95% confidence interval, 0.85-0.96). In conclusion, alpha2-macroglobulin, hyaluronic acid, and haptoglobin levels are independent predictors for significant hepatic fibrosis in chronic liver disease.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2010.25.1.67