Eradication of Helicobacter pylori increases ghrelin mRNA expression in the gastric mucosa

It has been suggested that Helicobacter pylori eradication may influence production of some peptides in the stomach, which can affect appetite. This hypothesis is controversial. To verify the hypothesis, we conducted this randomized controlled trial using H. pylori infected subjects without any gast...

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Bibliographic Details
Published in:Journal of Korean medical science 2010, 25(2), 135, pp.265-271
Main Authors: Lee, Eon Sook, Yoon, Yeong Sook, Park, Cheol-Young, Kim, Han-Seong, Um, Tae Hyun, Baik, Hyun Wook, Jang, Eun Jeong, Lee, Sangyeoup, Park, Hee Soon, Oh, Sang Woo
Format: Article
Language:English
Subjects:
Adult
Aged
Anti-Bacterial Agents - therapeutic use
Female
Gastric Mucosa - metabolism
Gastric Mucosa - microbiology
Gastroscopy
Ghrelin - blood
Ghrelin - genetics
Ghrelin - metabolism
Helicobacter Infections - drug therapy
Helicobacter Infections - genetics
Helicobacter Infections - metabolism
Helicobacter pylori
Humans
Male
Original
RNA, Messenger - metabolism
Tumor Necrosis Factor-alpha - genetics
Tumor Necrosis Factor-alpha - metabolism
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Summary:It has been suggested that Helicobacter pylori eradication may influence production of some peptides in the stomach, which can affect appetite. This hypothesis is controversial. To verify the hypothesis, we conducted this randomized controlled trial using H. pylori infected subjects without any gastrointestinal symptoms. The treatment group received triple H. pylori eradication therapy for 7 days and the control group received no medication. We measured ghrelin, obestatin and the tumor necrosis factor-alpha (TNF-alpha) mRNA levels in endoscopic biopsy specimens and the changes from baseline to follow-up. The plasma active n-octanoyl ghrelin and obestatin levels were measured in both groups. The ghrelin/obestatin ratios in plasma and gastric mRNA expression were calculated at baseline and follow-up. Ghrelin mRNA expression in the fundic mucosa after H. pylori eradication increased significantly compared to the control group (4.47+/-2.14 vs. 1.79+/-0.96, P=0.009), independent of inflammatory changes. However, obestatin mRNA expression decreased in the antral mucosa (-0.57+/-1.06 vs. 0.41+/-0.72, P=0.028). The treatment group showed a marginal increase (P=0.060) in plasma ghrelin/obestatin ratio. The TNF-alpha mRNA expression also decreased significantly with treatment. This randomized controlled trial demonstrates that H. pylori eradication increases ghrelin mRNA expression, independent of inflammatory cell changes.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2010.25.2.265