Association of abdominal obesity with atherosclerosis in type 2 diabetes mellitus (T2DM) in Korea

The aim of this study was to investigate the relationship between obesity, insulin resistance and atherosclerosis in type 2 diabetes mellitus (T2DM) patients. Total 530 patients with T2DM were included. To evaluate the severity of atherosclerosis, we measured the coronary artery calcification (CAC)...

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Bibliographic Details
Published in:Journal of Korean medical science 2008, 23(5), , pp.781-788
Main Authors: Cho, Minho, Park, Jong Suk, Nam, Jisun, Kim, Chul Sik, Nam, Jae Hyun, Kim, Hai Jin, Ahn, Chul Woo, Cha, Bong Soo, Lim, Sung Kil, Kim, Kyung Rae, Lee, Hyun Chul, Huh, Kap Bum
Format: Article
Language:English
Subjects:
Aged
Atherosclerosis - complications
Blood Pressure
Coronary Vessels - pathology
Diabetes Complications
Diabetes Mellitus, Type 2 - genetics
Female
Humans
Insulin Resistance
Korea
Male
Middle Aged
Obesity - complications
Obesity - genetics
Original
Triglycerides - metabolism
Tunica Intima - pathology
Tunica Media - pathology
의학일반
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Summary:The aim of this study was to investigate the relationship between obesity, insulin resistance and atherosclerosis in type 2 diabetes mellitus (T2DM) patients. Total 530 patients with T2DM were included. To evaluate the severity of atherosclerosis, we measured the coronary artery calcification (CAC) score, intima-media thickness (IMT) of the common carotid artery, and the ankle-brachial pressure index (ABPI). Subjects were classified according to body mass index (BMI), a marker of general obesity, and waist-to-hip ratio (WHR), a marker of regional obesity. The insulin sensitivity index (ISI) was measured by the short insulin tolerance test. All subjects were classified into four groups, according to BMI: the under-weight group, the normal-weight (NW) group, the over-weight (OW) group, and the obese (OB) group. WHR and systolic blood pressure, triglycerides (TG), HDL-cholesterol (HDLC), free fatty acids (FFA), fibrinogen, and fasting c-peptide levels were significantly different between BMI groups. TG, HDL-C, FFA, fibrinogen and ISI were significantly different between patients with and without abdominal obesity. In the OW group as well as in the NW group, carotid IMT, ABPI and CAC score were significantly different between patients with and without abdominal obesity. This study indicates that abdominal obesity was associated with atherosclerosis in T2DM patients.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2008.23.5.781