A case of a patient with both chorea and restless legs syndrome

The patient was a 44-yr-old man with end-stage renal disease who had developed chorea as a result of hypoglycemic injury to the basal ganglia and thalamus and who was subsequently diagnosed with depression and restless legs syndrome (RLS). For proper management, the presence of a complex medical con...

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Bibliographic Details
Published in:Journal of Korean medical science 2008, 23(3), , pp.533-536
Main Authors: Shin, Yoon-Kyung, Hong, Seung-Chul, Ihn, Yon Kwon, Jeong, Jong-Hyun, Han, Jin-Hee, Lee, Sung-Pil
Format: Article
Language:English
Subjects:
Adult
Analgesics, Opioid - therapeutic use
Anti-Dyskinesia Agents - therapeutic use
Case Report
Chorea - complications
Chorea - pathology
Citalopram - therapeutic use
Drug Therapy, Combination
Haloperidol - therapeutic use
Humans
Kidney Failure, Chronic - complications
Magnetic Resonance Imaging
Male
Restless Legs Syndrome - complications
Restless Legs Syndrome - drug therapy
Restless Legs Syndrome - pathology
Serotonin Uptake Inhibitors - therapeutic use
Tramadol - therapeutic use
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Summary:The patient was a 44-yr-old man with end-stage renal disease who had developed chorea as a result of hypoglycemic injury to the basal ganglia and thalamus and who was subsequently diagnosed with depression and restless legs syndrome (RLS). For proper management, the presence of a complex medical condition including two contrasting diseases, chorea and RLS, had to be considered. Tramadol improved the pain and dysesthetic restlessness in his feet and legs, and this was gradually followed by improvements in his depressed mood, insomnia, lethargy, and feelings of hopelessness. This case suggests that the dopaminergic system participates intricately with the opioid, serotoninergic, and noradrenergic systems in the pathophysiology of RLS and pain and indirectly of depression and insomnia.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2008.23.3.533