The prognostic significance of multiple station N2 in patients with surgically resected stage IIIA N2 non-small cell lung cancer

Mediastinal (N2) lymph node involvement is heterogeneous with huge variation in the extent and grouped together under stage IIIA. However, they showed a different survival even in the same stage. We tried to determine the prognostic implication of the multiple station N2 lymph node metastasis in sta...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Korean medical science 2008, 23(4), , pp.604-608
Main Authors: Lee, Jin Gu, Lee, Chang Young, Park, In Kyu, Kim, Dae Joon, Cho, Sang Ho, Kim, Kil Dong, Chung, Kyung Young
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma, Non-Small-Cell Lung - mortality
Carcinoma, Non-Small-Cell Lung - pathology
Female
Humans
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Male
Middle Aged
Neoplasm Metastasis
Neoplasm Staging
Original
Prognosis
Survival Rate
의학일반
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mediastinal (N2) lymph node involvement is heterogeneous with huge variation in the extent and grouped together under stage IIIA. However, they showed a different survival even in the same stage. We tried to determine the prognostic implication of the multiple station N2 lymph node metastasis in stage IIIA N2 non-small cell lung cancer (NSCLC). The survival of stage IIIA N2 was analyzed according to the number of N2 station and their survival was compared with that of stage IIIB. In stage IIIA N2 NSCLC, multivariate analysis indicated that multiple station N2 was one of the independent prognostic factors for poor survival. The 5-yr survival of multiple station N2 IIIA (20.4%) was lower than that of single station N2 IIIA (33.8%) significantly (p=0.016). but when it was compared with that of stage IIIB (15.5%), there was no difference. Therefore, we suggest that multiple station N2 should be considered similar to stage IIIB disease with regard to predicting survival and accordingly should receive a new position in the TNM staging system.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2008.23.4.604