Defective erythropoiesis in bone marrow is a mechanism of anemia in children with cancer

Evaluation of the mechanism of anemia in cancer patients might help to select patients for the more efficient use of erythropoietin (EPO, a growth factor for erythroid precursor cells). For this, we investigated whether the production of EPO responds to anemia and the bone marrow responds to EPO app...

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Bibliographic Details
Published in:Journal of Korean medical science 2002, 17(3), , pp.337-340
Main Authors: Kim, MunHee, Lee, JungHwa, Wu, ChanWuk, Cho, SungWon, Lee, KwangChul
Format: Article
Language:English
Subjects:
Anemia - etiology
Anemia - physiopathology
Blood Sedimentation
Bone Marrow - physiology
Child
Erythropoiesis - physiology
Erythropoietin - blood
Female
Humans
Male
Neoplasms - complications
Neoplasms - physiopathology
Receptors, Transferrin - blood
Solubility
Tumor Necrosis Factor-alpha - metabolism
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Summary:Evaluation of the mechanism of anemia in cancer patients might help to select patients for the more efficient use of erythropoietin (EPO, a growth factor for erythroid precursor cells). For this, we investigated whether the production of EPO responds to anemia and the bone marrow responds to EPO appropriately, and whether chronic inflammation is inhibitory to erythropoiesis in anemic cancer children. Serum levels of EPO, soluble transferrin receptor (sTfR), tumor necrosis factor (TNF)-alpha, and erythrocyte sedimentation rate (ESR) in anemic cancer children were measured by enzyme-linked immunosorbent assay and then the correlation coefficients between those parameters and hemoglobin (Hb) were determined. Both in leukemia and in solid tumor patients, there were significant inverse correlations between Hb and EPO (leukemia: tau=-0.547, p
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2002.17.3.337